BIZNOTE: Goodnight Pilates and Muscle Activation now open in north Morgan Junction – West Seattle Blog

West Seattle, Washington
(Photo courtesy Goodnight Pilates)
One of West Seattle’s newest businesses is now open at 5904 California SW: Goodnight Pilates and Muscle Activation. Proprietor Carrie Goodnight is occupying half the space that used to be DeSautel Chiropractic (now at 6553 California SW under the name Resolve Chiropractic.) Goodnight tells WSB, “After nearly 20 years of teaching Pilates (13 of them in West Seattle), I have expanded my skill set to include Muscle Activation Techniques.” She says combining Pilates with MAT (explained here) is a “powerful combination.” The new studio offers one-on-one lessons and bodywork, by appointment.
Carrie has done wonders for my injured hand and stiff shoulders!
Carrie did not solicit this reference but I want to praise her work and the many specialized treatments she offers incorporating Pilates and now MAT. I have been taking Pilates from Carrie for over 6 years and have loved every session with her and now, I am grateful to be receiving the healing  benefit of her added MAT therapy.  She is an amazingly gifted teacher and healer and I feel so blessed that she now has opened Goodnight Pilates and MAT convenient to me in West Seattle.  Believe me when I say that she is a GEM and worth so much more than her fee! 
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5 takeaways from Ravens' 34-6 win vs. Chargers – Ravens Wire

The Baltimore Ravens were able to move to 5-1 through their first six games of the 2021 season as they defeated the Los Angeles Chargers by the final score of 34-6. Baltimore was in control of the game from the start, and never let Los Angeles establish themselves or creep back into the contest.
There are plenty of takeaways from Sunday afternoon’s action on both sides of the ball for the Ravens. Multiple key contributors stepped up in a true team effort to defeat a very good football team.
Below we look at five takeaways from Baltimore’s Week 6 win over the Chargers.
(AP Photo/Terrance Williams)
Ravens QB Lamar Jackson didn’t exactly stuff the box score on Sunday against the Chargers. He finished the game completing 19 of 27 passes for 167 yards and one touchdown, while also throwing two interceptions. He also had 51 rushing yards on eight carries.
Despite Jackson not filling up the stat sheet, Baltimore won by 28 points in their most complete and dominant win of the season. The fourth-year signal caller played a huge role in the Ravens’ victory, and this game goes to show that Jackson doesn’t need to put up a massive stat line in order for Baltimore to dominate. He impacts the game in so many other ways that he is still able to leave a massive imprint on every contest he plays in, regardless of what the box score says.
Mandatory Credit: Tommy Gilligan-USA TODAY Sports
It’s no secret that over the last few weeks, the Ravens’ rushing attack has struggled. Baltimore’s ground game averaged just 3.4 yards per carry in Week 5 against the Indianapolis Colts, but it was a different story in Week 6 against Los Angeles.
The Ravens averaged 4.9 yards per carry on the ground as a team while spreading the ball around between Lamar Jackson and their three active running backs. While the team certainly misses J.K. Dobbins and Gus Edwards, they have found players who can at least make up for some of their production in Latavius Murray, Devonta Freeman, Le’Veon Bell and Ty’Son Williams. Now it’s a matter of the organization continuing to figure out the best ways to utilize each rusher.
(AP Photo/Nick Wass)
Rookie wide receiver Rashod Bateman made his NFL debut in Week 6 against the Chargers after missing the first month of the 2021 season with a core muscle injury. He didn’t disappoint in his first game, putting together an overall solid performance.
Bateman caught four passes for 29 yards on the day, with each of his catches resulting in a first down. He did drop a pass that directly resulted in a Lamar Jackson interception, but those mistakes can be ironed out with time. His six targets were tied for the most on the team with tight end Mark Andrews, so Jackson was looking his way often. It was a promising debut for the rookie and a glimpse of what’s to come from Bateman.
Mandatory Credit: Vincent Carchietta-USA TODAY Sports
Entering Week 6, the Chargers were one of the hottest teams in the NFL. Their offense led by quarterback Justin Herbert, running back Austin Ekler, wide receiver Keenan Allen and others were putting up points in bunches, and many thought that they would do the same to a struggling Baltimore defense. However, that wasn’t the case.
The Ravens’ defensive unit held the high-flying Los Angeles offense to just 4.4 yards per pass and 2.2 yards per rush on Sunday, only allowing them to score six points. They shut down the Chargers run game and never let Herbert get into a rhythm. When the Baltimore defense plays the way that they did against Los Angeles in Week 6, they can stop just about anybody.
(AP Photo/Terrance Williams)
Many had high hopes for the Ravens heading into the 2021 season, but a slew of injuries quickly cast a dark cloud upon how successful people thought the team could be. However, Baltimore showed in Week 6 that they are true contenders this year.
Despite losing so many key contributors to injury, the Ravens have fought through their bad luck and put together an impressive 5-1 record. Many new faces are making positive impacts, and the team is now starting to see a few of their injured players return to the field. As the season goes on, it’s likely that the team will only continue to improve. Baltimore has never lost sight of their goal to win a Super Bowl, and it’s shown with how they approach each and every week.
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Theme-Based Tourist Train Policy Ready To Roll – Swarajya

While the public transporter is relooking at the private train operation project to make it a feasible model, the Railways is, meanwhile, going ahead with the theme-based train scheme.
Firming up a policy to promote rail-based tourism, Indian Railways is likely to launch the scheme to lease out coaches to interested parties to run them as theme-based cultural, religious and other tourist circuit trains shortly.
The Railways’ move to privatise part of its train running operations earlier this year by inviting bids from private players for 109 railway passenger routes failed to generate interest with bidders citing a number of problems including lack of route flexibility and the absence of a rail regulator.
While the public transporter is relooking at the private train operation project to make it a feasible model, the Railways is, meanwhile, going ahead with the theme-based train scheme.
Aiming at going beyond Ramayan and Buddhist circuits, the Railways is targeting the state governments and private players in equal measure to start the tourist trains across the country.
Besides the Ramayana and Buddhist circuits, the IRCTC and a few state tourism departments are also running some tourist services like Maharaja and the Palace on Wheels trains.
However, the earnings from these tourist trains are not more than Rs 200 crore a year. “While the passenger revenue is pegged at about Rs 51,000 crore, the earnings from tourist trains is not very significant,” said a senior Railway Ministry official involved in finalising the theme-based trains.
The official said the theme-based trains have good potential in the country as our domestic tourism is looking up now.
Whether by state governments or private tour operators, coaches would be leased for a minimum period of five years and will be extendable till the codal life of coaches.
Locomotives and train drivers would be provided by the Railways and it will levy haulage charges, nominal stabling charges, and lease charges.
Interested parties would decide on the business model including tariff and itinerary. Branding of trains and advertising inside coaches are also permitted as part of the business model of the private players.
The steps are expected to tap the potential of the tourism sector and to leverage the core strengths of the professionals of the tourism sector in tourism activities like marketing, hospitality, integration of services, reach with customer base, expertise in identification of tourist circuits.
The coach can be refurbished by the interested parties to attract customers.
Arun Kumar Das is a senior journalist covering railways. He can be contacted at [email protected]

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Mathematical model predicts best way to build muscle – Phys.org


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August 23, 2021
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Researchers have developed a mathematical model that can predict the optimum exercise regimen for building muscle.

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The researchers, from the University of Cambridge, used methods of theoretical biophysics to construct the , which can tell how much a specific amount of exertion will cause a to grow and how long it will take. The model could form the basis of a software product, where users could optimize their exercise regimens by entering a few details of their individual physiology.
The model is based on earlier work by the same team, which found that a component of muscle called titin is responsible for generating the chemical signals which affect muscle growth.
The results, reported in the Biophysical Journal, suggest that there is an optimal weight at which to do resistance training for each person and each muscle growth target. Muscles can only be near their maximal load for a very short time, and it is the load integrated over time which activates the cell signaling pathway that leads to synthesis of new muscle proteins. But below a certain value, the load is insufficient to cause much signaling, and exercise time would have to increase exponentially to compensate. The value of this critical load is likely to depend on the particular physiology of the individual.
We all know that exercise builds muscle. Or do we? “Surprisingly, not very much is known about why or how exercise builds muscles: there’s a lot of anecdotal knowledge and acquired wisdom, but very little in the way of hard or proven data,” said Professor Eugene Terentjev from Cambridge’s Cavendish Laboratory, one of the paper’s authors.
When exercising, the higher the load, the more repetitions or the greater the frequency, then the greater the increase in muscle size. However, even when looking at the whole muscle, why or how much this happens isn’t known. The answers to both questions get even trickier as the focus goes down to a single muscle or its individual fibers.
Muscles are made up of individual filaments, which are only 2 micrometers long and less than a micrometer across, smaller than the size of the muscle cell. “Because of this, part of the explanation for muscle growth must be at the molecular scale,” said co-author Neil Ibata. “The interactions between the main structural in muscle were only pieced together around 50 years ago. How the smaller, accessory proteins fit into the picture is still not fully clear.”
This is because the data is very difficult to obtain: people differ greatly in their physiology and behavior, making it almost impossible to conduct a controlled experiment on muscle size changes in a real person. “You can extract muscle cells and look at those individually, but that then ignores other problems like oxygen and glucose levels during exercise,” said Terentjev. “It’s very hard to look at it all together.”
Terentjev and his colleagues started looking at the mechanisms of mechanosensing—the ability of cells to sense mechanical cues in their environment—several years ago. The research was noticed by the English Institute of Sport, who were interested in whether it might relate to their observations in muscle rehabilitation. Together, they found that muscle hyper/atrophy was directly linked to the Cambridge work.
In 2018, the Cambridge researchers started a project on how the proteins in muscle filaments change under force. They found that main muscle constituents, actin and myosin, lack binding sites for signaling molecules, so it had to be the third-most abundant muscle component—titin—that was responsible for signaling the changes in applied force.
Whenever part of a molecule is under tension for a sufficiently long time, it toggles into a different state, exposing a previously hidden region. If this region can then bind to a small molecule involved in cell signaling, it activates that molecule, generating a chemical signal chain. Titin is a giant protein, a large part of which is extended when a muscle is stretched, but a small part of the molecule is also under tension during muscle contraction. This part of titin contains the so-called titin kinase domain, which is the one that generates the chemical signal that affects muscle growth.
The molecule will be more likely to open if it is under more force, or when kept under the same force for longer. Both conditions will increase the number of activated signaling molecules. These molecules then induce the synthesis of more messenger RNA, leading to production of new muscle proteins, and the cross-section of the muscle cell increases.
This realization led to the current work, started by Ibata, himself a keen athlete. “I was excited to gain a better understanding of both the why and how of muscle growth,” he said. “So much time and resources could be saved in avoiding low-productivity exercise regimens, and maximizing athletes’ potential with regular higher value sessions, given a specific volume that the athlete is capable of achieving.”
Terentjev and Ibata set out to constrict a that could give quantitative predictions on muscle growth. They started with a simple model that kept track of titin molecules opening under force and starting the signaling cascade. They used microscopy data to determine the force-dependent probability that a titin kinase unit would open or close under force and activate a signaling molecule.
They then made the model more complex by including additional information, such as metabolic energy exchange, as well as repetition length and recovery. The model was validated using past long-term studies on muscle hypertrophy.
“Our model offers a physiological basis for the idea that muscle growth mainly occurs at 70% of the maximum load, which is the idea behind resistance training,” said Terentjev. “Below that, the opening rate of titin kinase drops precipitously and precludes mechanosensitive signaling from taking place. Above that, rapid exhaustion prevents a good outcome, which our model has quantitatively predicted.”
“One of the challenges in preparing elite athletes is the common requirement for maximizing adaptations while balancing associated trade-offs like energy costs,” said Fionn MacPartlin, Senior Strength & Conditioning Coach at the English Institute of Sport. “This work gives us more insight into the potential mechanisms of how muscles sense and respond to load, which can help us more specifically design interventions to meet these goals.”
The model also addresses the problem of muscle atrophy, which occurs during long periods of bed rest or for astronauts in microgravity, showing both how long can a muscle afford to remain inactive before starting to deteriorate, and what the optimal recovery regimen could be.
Eventually, the researchers hope to produce a user-friendly software-based application that could give individualized exercise regimens for specific goals. The researchers also hope to improve their model by extending their analysis with detailed data for both men and women, as many exercise studies are heavily biased towards male athletes.


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Body builders aren’t necessarily the strongest athletes


More information: Neil Ibata et al, Why exercise builds muscles: titin mechanosensing controls skeletal muscle growth under load, Biophysical Journal (2021). DOI: 10.1016/j.bpj.2021.07.023

Journal information: Biophysical Journal

Citation: Mathematical model predicts best way to build muscle (2021, August 23) retrieved 21 October 2021 from https://phys.org/news/2021-08-mathematical-muscle.html
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Seniors Dying After COVID Vaccine Labeled as Natural Causes – TideWater Latest News

This article was beforehand revealed February 2, 2021, and has been up to date with new data.
By February 2021, around the world, reviews have been already pouring in of individuals dying shortly after receiving the COVID-19 vaccine. In many instances, they die immediately inside hours of getting the shot. In others, demise happens inside the span of a few weeks.
One notable case is baseball legend Hank Aaron, 86, who died January 22, 2021, 17 days after publicly getting vaccinated for COVID-19.1,2 He mentioned on the time that he hoped different Blacks would observe his lead and get their vaccines too.
According to information reviews, he died “peacefully in his sleep” of pure causes, with the health worker claiming there was no indication the vaccine was related to his demise.3 Aaron was well-known for being the home-run king of baseball, and broke Babe Ruth’s report when he hit homerun No. 715; he had hit 755 by the point he retired from the game.
In associated information, Norway recorded 29 senior citizen deaths within the wake of their vaccination push.4 Most have been over the age of 75. A complete of 42,000 Norwegians had by that point obtained the vaccine.
While well being officers initially downplayed any connection to the vaccine, a report in Bloomberg suggests the Norwegian Medicines Agency are actually reconsidering. At the time of the deaths, the Pfizer vaccine was the one COVID-19 vaccine out there in Norway, so “all deaths are thus linked to this vaccine,” the company informed Bloomberg.5
“‘There are 13 deaths which have been assessed, and we’re conscious of one other 16 deaths which might be presently being assessed,’ the company mentioned. All the reported deaths associated to ‘aged folks with severe primary problems,’ it mentioned.
‘Most folks have skilled the anticipated unwanted side effects of the vaccine, comparable to nausea and vomiting, fever, native reactions on the injection web site, and worsening of their underlying situation’ …
The findings have prompted Norway to counsel that COVID-19 vaccines could also be too dangerous for the very outdated and terminally ailing, essentially the most cautious assertion but from a European well being authority.
The Norwegian Institute of Public Health judges that ‘for these with essentially the most extreme frailty, even comparatively gentle vaccine unwanted side effects can have severe penalties. For those that have a really brief remaining life span anyway, the good thing about the vaccine could also be marginal or irrelevant.’”
Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, commented that the deaths need to be “put into context with the population they occurred in.”6
In different phrases, they have been outdated and outdated folks die. It’s hypocrisy at its best. When seniors die earlier than vaccination, it is because of COVID-19 and one thing have to be completed to forestall it, however once they die after vaccination, they die of pure causes and no preventive motion is critical.
The World Health Organization added that since there was “no certain connection” of the vaccines to Norway’s deaths, there isn’t any cause to discontinue giving it to senior residents.
Interestingly, a number of areas have reported that deaths are quickly rising AFTER vaccination applications are applied. The information tales do not truly say it straight out, however when you take a look at dates given, it raises questions. One such instance is what occurred in Gibraltar on the southern tip of Spain, which has a inhabitants of 34,000.
The space rolled out its vaccination program January 9, 2021, utilizing the Pfizer mRNA vaccine. By January 17, 2021, 5,847 doses had been administered (about 17% of the inhabitants), in response to a report by MedicalXpress.7
The curious factor about it’s that the realm’s first recorded demise from COVID-19 did not happen till mid-November 2020. By January 6, three days earlier than the vaccination program started, the overall COVID-19-related demise toll reportedly stood at 10.
Then, by January 17, the overall demise toll had immediately skyrocketed to 45. In different phrases, 35 folks died within the first eight days of the vaccination program. Most have been of their 80s and 90s.
Chief Minister Fabian Picardo mentioned, “This is now the worst loss of life of Gibraltarians in over 100 years. Even in war, we have never lost so many in such a short time.”8 None of the deaths was being blamed on the vaccine, nevertheless. Instead, they loosely blamed them on the brand new variant of SARS-CoV-2.
Other areas are additionally reporting “outbreaks” of COVID-19, leading to elevated demise tolls, after the rollout of vaccinations. Case in level: In Auburn, New York, a COVID-19 outbreak started December 21, 2020, in a Cayuga County nursing house.9,10 Before this outbreak, nobody within the nursing house had died from COVID-19.
The subsequent day, December 22, they began vaccinating residents and employees. The first demise was reported December 29, 2020. Between December 22, 2020, and January 9, 2021, 193 residents (80%) obtained the vaccine, as did 113 employees members.
As of January 9, 2021, 137 residents had been contaminated and 24 had died. Forty-seven employees members had additionally examined optimistic for SARS-CoV-2 and one was on life-support.
Considering we’re additionally seeing instances during which wholesome younger and middle-aged people die inside days of receiving the vaccine, it isn’t inconceivable that the vaccine might need one thing to do with these dramatic rises in deaths among the many aged in numerous elements of the world. In reality, I’d anticipate it.
You can relaxation assured, nevertheless, that the general public well being authorities and media is not going to report these observations. Anything that conflicts with vaccine security and effectiveness might be deliberately and universally buried. This is exactly their modus operandi of the previous three many years, so it is actually as much as every particular person to do their very own analysis.
When the worldwide vaccine marketing campaign was lower than a month outdated in most locations, reviews of great unwanted side effects had already began pouring in. Many shared their private experiences on social media networks. Disturbingly, many additionally had their tales censored as deceptive or false. Videos, particularly, are typically taken down.
Aside from sudden demise inside hours or days,11,12,13,14,15 examples of unwanted side effects amongst survivors of the Pfizer and Moderna mRNA vaccines embody:
To get a really feel for what’s actually taking place, try members solely web site, Prezi. Once you create a login, you’ll be able to entry tales from numerous social media posts detailing antagonistic reactions. It’s a moderately surprising compilation that’s nicely value sharing with household and associates who’re nonetheless on the fence about getting the vaccine.
Many say they “feel weird” and that they “don’t feel like myself.” Dizziness, racing coronary heart and excessive hypertension appear to be a standard grievance, as is extreme, power seemingly “unbreakable” headache that doesn’t reply to treatment. Many describe the ache they really feel of their physique as “being run over by a bus” or “being beaten with a bat.”
Some report swollen and painful lymph nodes, extreme muscle ache and gastrointestinal points. Symptoms mimicking stroke are being reported, regardless that CT scans present nothing of concern. One such report is from a 19-year-old woman. Several report deadly coronary heart assaults claiming the lives of somebody they love.
Psychological results are additionally beginning to creep in. One lady who’s on chemotherapy reviews “mood changes with intermittent periods of elation and mild euphoria.” Bouts of hysteria, despair, mind fog, confusion and dissociation are additionally being reported, as is an lack of ability to sleep.
One individual reviews having misplaced “the voice in my head,” which I believe is the power to listen to your self assume. Another reviews shedding the power to formulate phrases about half an hour after getting the primary dose of vaccine, and a 3rd reviews “struggling for lost words.” Loss of style and/or scent are additionally being reported, in addition to style alterations. Several say they’ve developed a metallic style since their vaccination.
One pregnant lady reported spontaneous rupture of the amniotic sac leading to untimely supply. Another lady’s child was discovered to haven’t any heartbeat two days after her vaccination and was delivered stillborn. Several describe results suggesting vascular issues, comparable to pores and skin blotchiness and fingers turning blue.
We see mass cell activation syndromes. The medical signs are going to be the inflammatory ailments. We hear all people calling it ‘lengthy haul COVID’ — the intense, profound, crippling fatigue, the shortcoming to supply power out of your mitochondria. It’s not lengthy haul COVID. It’s precisely what it at all times was — myalgic encephalomyelitis, irritation of the mind and the spinal twine. ~ Judy Mikovits Ph.D.
While individuals are hoping and praying their unwanted side effects might be non permanent, a good portion say they’re nonetheless battling the consequences one or two weeks after their shot. Time will inform whether or not they transform everlasting, however contemplating the truth that the mRNA vaccines reprogram your DNA, there is definitely the likelihood that they is perhaps long-lasting.
I lately interviewed mobile and molecular biologist Judy Mikovits, Ph.D., concerning the mechanics of COVID-19 mRNA vaccines, that are really gene remedy. They’re not typical vaccines. Compare the abstract of reported unwanted side effects within the part above to the longer-term unwanted side effects she suspects will change into commonplace, primarily based on the mechanics and organic results of those gene remedy “vaccines”:
Migraines
Involuntary muscle actions, tics and spasms
Parkinson’s illness
Microvascular problems
Cancers
Severe ache syndromes
Bladder issues
Kidney illness
Psychological problems comparable to psychosis and autism spectrum
Neurodegenerative ailments
Sleep problems
Infertility and different reproductive issues
The underlying causes, in response to Mikovits, are neuroinflammation and dysregulation of the immune system and endocannabinoid system.
“It’s the brain on fire,” she says. “You’re going to see ticks, you are going to see Parkinsonian illness, you are going to see ALS, you are going to see issues like this creating at extraordinarily fast charges, and it is irritation of the mind.
We see mass cell activation syndromes. The medical signs are going to be the inflammatory ailments. We hear all people calling it ‘lengthy haul COVID’ — the intense, profound, crippling fatigue, the shortcoming to supply power out of your mitochondria.
It’s not lengthy haul COVID. It’s precisely what it at all times was — myalgic encephalomyelitis, irritation of the mind and the spinal twine. What they’re deliberately doing is killing off [certain] populations.”
According to a current report by The Defender,27 there are vital discrepancies within the information Moderna submitted to the U.S. Food and Drug Administration:
“Moderna’s reported demise charge for its COVID vaccine, primarily based on medical trials, is 5.41 instances better than Pfizer’s. Yet neither are consultant of nationwide demise charges — that is a pink flag …
The Moderna vaccine arm demise charge of 0.36 deaths/100K/day) is 5.14 instances greater than Pfizer’s (0.07 deaths/100K/day). This massive discrepancy deserves discover and requires clarification.
If Moderna’s on-vaccine demise charge is to this point beneath the nationwide demise charge and in addition concurrently greater than 5 instances better than Pfizer’s on-vaccine demise charge, then Pfizer’s research pattern seems even much less consultant of all the inhabitants. This, too, requires due consideration …
When evaluating [Moderna’s] study-wide variety of deaths per day per 100K for the research to that of all the U.S. inhabitants from 2019, I used to be shocked: the nationwide variety of deaths per day per 100K is 2.44.
Moderna’s screening course of and exclusion standards within the trial led to proof that the final inhabitants is dying at a charge 6.3 instances better than the demise charge within the Moderna trial — which implies the Moderna research, together with its estimated efficacy charge and the vaccine’s alleged security profile — can not probably be related to a lot of the U.S. inhabitants.
The super-healthy cohorts studied by Moderna are under no circumstances consultant of the U.S. inhabitants. Most deaths from COVID-19 contain pre-existing well being situations of the kinds excluded from each Pfizer and Moderna trials …
Those enrolling within the post-market surveillance research should know the abject absence of any related data on efficacy and danger for them. In their zeal to assist humanity, or to assist themselves, these folks might very nicely be strolling right into a scenario that can trigger autoimmunity because of pathogenic priming, probably resulting in illness enhancement ought to they change into contaminated following vaccination.”
What may account for Moderna’s gene remedy “vaccine” inflicting greater than 5 instances extra deaths than Pfizer’s? One chance raised in The Defender’s article is that they didn’t “screen out unsafe epitopes to reduce autoimmunity due to homology between parts of the viral protein and the human proteome.”
According to a 2020 paper28 within the Journal of Translational Autoimmunity, “Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity,” noting that the identical might apply post-vaccination.
As defined on this paper, all however considered one of SARS-CoV-2 immunogenic epitopes are much like human proteins. Epitopes29 are websites on the virus that permit antibodies or cell receptors in your immune system to acknowledge it.
This is why epitopes are additionally known as “antigenic determinants,” as they’re the elements which might be acknowledged by an antibody, B-cell receptor or T-cell receptor. Most antigens — substances that bind particularly to an antibody or a T-cell receptor — have a number of completely different epitopes, which permit it to be acknowledged by a number of completely different antibodies.
According to the creator, some epitopes may cause “autoimmunological pathogenic priming due to prior infection or following exposure to SARS-CoV-2 … following vaccination.”
In different phrases, when you’ve had the an infection as soon as, and get reinfected (both by SARS-CoV-2 or a sufficiently comparable coronavirus), the second bout has an excellent potential to be extra extreme than the primary. Similarly, when you get vaccinated and are then contaminated with SARS-CoV-2, your an infection could also be extra extreme than had you not been vaccinated.
For this cause, “these epitopes should be excluded from vaccines under development to minimize autoimmunity due to risk of pathogenic priming,” the paper warns. The summary lays out the fundamentals of the pathogenic priming course of.30 As famous in The Defender:31
“Thus, concern over vaccine-induced pathogenic priming is not zero, but it may be less than COVID-19 vaccines that use more than one SARS-CoV-2 protein. However, the hyper-focused IgG response to the fewer antigens could cause hyperimmunization, a condition considered ripe for off-target autoimmunity attacks.”
The Defender factors out that vaccine trials by no means use inert placebos. Instead, many use one other vaccine. By doing so, they successfully conceal unwanted side effects. In the case of Moderna, a complete of 13 folks died within the trial, seven within the vaccine group and eight within the placebo group. One extreme antagonistic occasion within the placebo group, nevertheless, was relabeled as a demise, and one demise within the vaccine group was relabeled as a extreme antagonistic occasion.
In the vaccine group, deaths have been listed as cardio-respiratory arrest, coronary heart assault, multisystem organ failure, head damage and suicide. None of the deaths was linked to the vaccine.
However, as famous in The Defender, coronary heart assaults can contain autoimmunity and have been seen in post-vaccinations earlier than. Multisystem organ failure can be “consistent with autoimmunity against ubiquitously expressed proteins as a result of vaccination.”
“The suicide cannot be ruled out as not due the vaccine, either,” The Defender writes, noting it could possibly be associated to “autoimmunity against oxytocin or serotonin receptors,” which could end in “devastating depression.”
Indeed, prezi.com contains quite a lot of reviews of individuals saying they’ve skilled nervousness and despair following their vaccination. Depression can be a potential consequence of neuroinflammation, as famous by Mikovits.
While each Pfizer and Moderna report low charges of unwanted side effects — Moderna’s being simply 0.5% — the charges of unwanted side effects in the true world look like terribly excessive. Data are nonetheless exhausting to come back by, but when we go by preliminary information reported in early 2021 by the U.S. Centers for Disease Control and Prevention,32 we find yourself with a facet impact charge in the true world of two.79%.
By December 18, 2020, 112,807 Americans had obtained their first dose of COVID-19 vaccine. Of these, 3,150 suffered a number of “health impact events,” outlined as being “unable to perform normal daily activities, unable to work, required care from doctor or health care professional.” If you divide the variety of reported unwanted side effects with the quantity that obtained the vaccine, you get a facet impact charge of two.79%.
If you then extrapolate that to the overall U.S. inhabitants of 328.2 million, we could also be taking a look at 9,156,780 Americans struggling vaccine accidents if everybody will get vaccinated.
In an attention-grabbing flip of occasions, a TV station used its Facebook page to ask individuals who had misplaced an unvaccinated beloved one to COVID-19 to contact them for a narrative, however what they obtained was an avalanche of tales of vaccine accidents and deaths as an alternative.33,34 Below is a sampling of feedback posted on the positioning. As of October 12, 2021, greater than 254,000 folks had responded, with tens of hundreds of them speaking concerning the vaccine’s antagonistic reactions.
To keep away from changing into a tragic statistic, I urge you to evaluation the science very fastidiously earlier than making up your thoughts about this experimental gene remedy. Also keep in mind that the lethality of COVID-19 is definitely surprisingly low. It’s decrease than the flu for these underneath the age of 60.35
If you are underneath the age of 40, your danger of dying from COVID-19 is simply 0.01%, which means you might have a 99.99% likelihood of surviving the an infection. And you might enhance that to 99.999% when you’re metabolically versatile, insulin delicate, and vitamin D replete.
So, actually, what are we defending in opposition to with a COVID-19 vaccine? These mRNA vaccines aren’t even designed to forestall an infection, solely to scale back the severity of signs and hospitalization. Meanwhile, they may probably make you sicker when you’re uncovered to the virus, and/or trigger persistent severe unwanted side effects comparable to these reviewed above.

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Saints Designate LB Kwon Alexander, DE Marcus Davenport, WR Tre'Quan Smith For Return – profootballrumors.com

The Saints are about to get some reinforcement. The team designated linebacker Kwon Alexander, defensive end Marcus Davenport, and wide receiver Tre’Quan Smith for return from injured reserve today, reports NFL Network’s Tom Pelissero (via Twitter).
Alexander (elbow) and Davenport (shoulder) were both placed on IR in mid-September, meaning the earliest they could have returned was Week 5.
The Saints moved Davenport back into their starting lineup to start this season, providing the player with an opportunity to re-establish himself opposite Cameron Jordan. Davenport registered a sack and two QB hits in the Saints’ dominant Week 1 win over the Packers.
Alexander worked his way back from a December Achilles tear to be ready in time for the Saints’ opener, but this latest injury continued a rough run of health for the former Buccaneers standout. Alexander suffered a torn ACL in 2018, though he still landed a nice contract from the 49ers. However, the veteran linebacker sustained a pectoral muscle tear in his first 49ers season.
Smith landed on IR a bit earlier than his defensive teammates after suffering a hamstring injury. The injury dogged Smith for several weeks, as he tried and failed to come back from it twice. It caused the former third-round pick to miss extensive training camp time.
While the Saints will happily welcome back this trio, they’ll still be without one of the most notable players. While wideout Michael Thomas was eligible to return from PUP this week, NFL Network’s Ian Rapoport notes (via Twitter) that there hasn’t been any news on his potential activation.
Photo courtesy of USA Today Sports Images.
My New Orleans Saints will almost be at full strength after their bye week. It’s been reported that WR Michael Thomas won’t be ready to return for a couple of more weeks after bye week. But we should be getting back WR Deonte’ Harris after the bye week, hopefully.
Kwon is a beast
When Kwon is healthy he’s one of the best LB’s in the NFL.
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Why is the Rabies CFR So High? – News-Medical.net

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The word rabies stirs up fears of a horrible death, though today this is mostly due to stories from the past than current experience, mercifully. Caused by the rabies virus, the disease is known to occur in over 150 countries.
Rabies
Image Credit: Ezume Images/Shutterstock.com
Most rabies in humans is transmitted by the saliva of dogs, through a bite or nip that breaks the skin. In fact, 99 of every 100 cases in humans is estimated to occur this way. Thus, breaking the transmission chain can be achieved by vaccinating dogs against the disease, and preventing dog bites.
Rabies is responsible for over 55,000 deaths every year, worldwide, mostly in remote and rural areas of developing regions. While Asia, Latin America, and Africa see most of these fatal events, rabies deaths are uncommon in the USA.
In the USA, stray dogs are not tolerated and pet dogs are mandatorily vaccinated against rabies, among other illnesses. In most countries within the above-named regions, dogs continue to cause rabies.
Not only are the chances of being bitten high in these regions, but the ability to access treatment in a timely and adequate fashion is very low. Rabies vaccines may not be routinely available in the rural settings where most exposure happens, and rabies immunoglobulins, required for category III bites, is almost always unavailable. This contributes markedly to the high mortality rate, as the highly protective rabies vaccine is often not available in these resource-poor locations.
Unfortunately, the development of symptoms is a harbinger of a fatal outcome. For this reason, all bites by dogs, cats, foxes, raccoons, bats, skunks, and almost any carnivore, except for rodents, should be washed immediately with plenty of soap and water.
Further steps should be taken after urgent consultation with a medical professional, depending on the local risk level and the type of animal, as well as its health status.
Rabies affects nerve cells almost exclusively, and it is the ability to invade the central nervous system that defines this disease.
The antigen-presenting cells, such as the dendritic cells, fail to pick up the traces of the virus and present them to innate and adaptive immune cells to clear the infection. As the virus continues to replicate in the tissue around the wound, at a low level, over a month to six weeks, it binds to the post-synaptic neurotransmitter receptors, causing its uptake into the motor end-plate – the structure that mediates neuromuscular impulse transmission.
Some studies show that this initial local replication is not uniformly present, with some strains entering the axon terminals directly.
Having achieved its aim of entering the nerve, its target cell, it spreads backward to the spinal cord, and the brain, racing along the nerves from synapse to synapse inside the covering of the Schwann cell that envelopes the nerve axon. This is mediated by the rabies virus G protein, which allows it to move from the post-synaptic to the pre-synaptic site.
The viral P protein may be involved in the limitation of viral replication. It also antagonizes the antiviral interferon response and thus enables immune evasion. Moreover, it mediates the entry of the virus into the peripheral nerve axons.
At this point, symptoms like nerve pain and numbness, or tingling, may begin. Once the virus reaches the brain, it spreads via the widespread nicotinic receptors of the brain. It also spreads outward to involve the peripheral nerves and the autonomic nervous system, accounting for many of the symptoms in progressive disease.
It is finally transported in the reverse direction to the salivary glands and is then found in the saliva, to cause further infections.
Rabies is almost invariably fatal once the virus reaches the central nervous system (CNS), which takes about 30-50 days, depending on how far away the wound site is from the brain. For this reason, the disease onset is rapid with wounds on the face compared to those on the foot.
This interval is extremely helpful in allowing the bitten exposed person or animal to be vaccinated against the virus, and to receive anti-rabies immunoglobulin to neutralize whatever viral particles are in the wound.
Medical students learn that if a patient with rabies does not die within a few days, the diagnosis of rabies is wrong. This underlines the almost invariably fatal outcome of this disease. Despite extremely rare reports of a very small number of survivors, mostly infected via bat-originated rabies viruses, almost all of them have marked deficits of neurological function.
Survival with recovery was notably described with Jeanna Geise in the USA after being on the so-called Milwaukee Protocol that put her into a coma while her immune system responded to the virus. This outcome has never been replicated, however.  
Why is rabies such an overwhelming challenge, even though the inflammation and neuronal abnormalities were seen in the brain at autopsy is slight, and though the virus has not been found to invade the circulation?
The most significant factor underlying the lethal outcome of an RV infection appears to be the neuronal dysfunction due to drastically inhibited synthesis of proteins required in maintaining neuronal functions
Most viral infections are vulnerable to antiviral drugs, which operate by inhibiting the viral lifecycle that is essential to productive infection. However, the rabies virus is adept at evading these antivirals as well as the host immune response.
The immune response in a rabid animal, in laboratory experiments, shows both antibodies and cellular immunity being activated to clear the virus. However, the issue is the inability of the infected animal to enhance the BBB permeability so that immune antibodies and cells can cross into the CNS.
Even after a virus infects the CNS, early viral clearance by the immune response is typically associated with complete or near-complete.
Rabies virus spread via the motor nerve pathways is not associated with marked CNS inflammation or with any neurological deficit. Even after it enters the brain, the motor nerve cells continue to function normally until the final acute stage. The cerebrospinal fluid also does not show the influx of immune cells as would be expected during widespread inflammation.
In rabid dogs, it has been observed that muscle micro-RNA (ribonucleic acid) molecules bind to the viral RNA to restrict viral replication and translation. The low viral RNA copy number and protein levels help to lull the immune system into false security even while replication is taking place. This restriction of replication also keeps neurons intact so that the virus can hitchhike rapidly on them to the CNS.
This explains why early postexposure prophylaxis (PEP) is required and effective in preventing rabies in humans following exposure.
The virus exploits the blood-brain barrier (BBB) to achieve self-protection. The BBB is a discontinuous membrane that prevents the entry of cells and large molecules, including proteins, into the brain. Normally, inflammation of the brain causes the BBB to become more porous as the tight junctions between cells are reduced.
This allows immune cells and antibodies to enter the brain and counter the infection, though it also, often, causes neuronal damage and correlates with neurological symptoms.
With the rabies virus, however, the blood-brain barrier remains impermeable despite the entry of the virus, perhaps because the virus has the ability to prevent inflammation and the resulting release of cytokines and chemokines. Researchers have suggested that “at some time after the virus has reached the CNS tissues, the BBB in the cerebellum becomes refractory to the signals that trigger enhanced permeability”.
This means that the brain, and the virus, are locked off from the immune response or antiviral drugs. The mechanism by which this is achieved remains unknown but could be highly promising in its potential for the management of rabies. It could also help treat neurodegenerative diseases (such as Alzheimer’s, Parkinson’s, or multiple sclerosis) in which the BBB is abnormally permeable.
The possibility of enhancing the BBB permeability to allow rabies virus neutralizing antibodies and immune cells to enter the CNS and clear the virus is being explored by many researchers.
Inappropriately high inflammatory reactions can also lead to severe disease or death in viral infections of the CNS. Interestingly, laboratory-weakened rabies virus strains induce a strong and even lethal immune and inflammatory reaction with activation of the dendritic cells. This shows that mild inflammation is necessary for viral clearance and survival after rabies infection.
In fact, the virus, like an evil genius, alters the immune signaling pathways themselves so that the immune T cells undergo apoptosis, rather than destroying the virus.
Neuroinvasiveness, neurotropism, and neurovirulence are the major defining characteristics of RV (rabies virus). To infect the CNS, pathogenic street RVs have acquired the ability for rapid entry and efficient spread, while producing only low amounts of viral RNA and proteins in order to prevent cell injury.”
The absence of neuronal apoptosis compared with the induction of apoptosis in the T cells that could be protective, allows the virus to spread widely and cause lethal infection – the so-called “subversive neuroinvasive strategy of rabies virus.”
Last Updated: Oct 20, 2021
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Dr. Liji Thomas is an OB-GYN, who graduated from the Government Medical College, University of Calicut, Kerala, in 2001. Liji practiced as a full-time consultant in obstetrics/gynecology in a private hospital for a few years following her graduation. She has counseled hundreds of patients facing issues from pregnancy-related problems and infertility, and has been in charge of over 2,000 deliveries, striving always to achieve a normal delivery rather than operative.
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China's Fanbo Zeng bets on himself with Ignite as stepping-stone to NBA stardom – San Francisco Chronicle

Fanbo Zeng practices at the Ultimate Fieldhouse, Tuesday, Oct. 19, 2021, in Walnut Creek, Calif. Zeng, 18, plays as a forward for the NBA G League Ignite.
Fanbo Zeng practices at the Ultimate Fieldhouse, Tuesday, Oct. 19, 2021, in Walnut Creek, Calif. Zeng, 18, plays as a forward for the NBA G League Ignite.
Fanbo Zeng practices at the Ultimate Fieldhouse, Tuesday, Oct. 19, 2021, in Walnut Creek, Calif. Zeng, 18, plays as a forward for the NBA G League Ignite.
Fanbo Zeng practices at the Ultimate Fieldhouse, Tuesday, Oct. 19, 2021, in Walnut Creek, Calif. Zeng, 18, plays as a forward for the NBA G League Ignite.
Fanbo Zeng’s sneaker seen during practice at the Ultimate Fieldhouse, Tuesday, Oct. 19, 2021, in Walnut Creek, Calif. Zeng, 18, plays as a forward for the NBA G League Ignite.
Fanbo Zeng poses with the Chinese flag while at Windermere Prep outside Orlando.
Fanbo Zeng practices at the Ultimate Fieldhouse, Tuesday, Oct. 19, 2021, in Walnut Creek, Calif. Zeng, 18, plays as a forward for the NBA G League Ignite.
Fanbo Zeng dunks during a game his sophomore year at Windermere Prep outside Orlando in 2020.
The future of Chinese basketball speaks near-flawless English, devours Chick-fil-A spicy chicken sandwiches whenever he gets the chance, and doesn’t want to hear arguments about why Michael Jordan was better than LeBron James.
“LeBron is the GOAT,” said Fanbo Zeng, a 6-foot-11, 197-pound combo forward who recently de-committed from Gonzaga to sign with NBA G League Ignite — a developmental team created last year to provide elite prospects an alternative to college basketball.
On a sunny Thursday afternoon at Ignite’s Walnut Creek headquarters, Zeng had just finished shooting a video with a website that specializes in luxury sneakers. One of Ignite’s big draws is the increased marketing opportunities that come with being a professional.
Though Zeng isn’t as prized by NBA scouts as teammates Jaden Hardy, Michael Foster, Scoot Henderson and Dyson Daniels, he might have a bigger following. Zeng’s Instagram inbox is filled with messages from Chinese fans who hope he can become the next Yao Ming. Still three months shy of his 19th birthday, Zeng is poised to announce a lucrative shoe deal.
China-based companies hardly care that the COVID-19 pandemic has kept him from playing a competitive game in nearly two years. In the more than decade since Yao retired, China — the NBA’s top overseas market — has been desperate for someone, anyone, to replace Yao as a global name.
An estimated 300 million people play basketball in China, but just six Chinese players have reached the NBA, with Yao the only one to have carved out a notable career. Zhou Qi, a second-round pick by the Rockets in 2016, is the lone Chinese-born player drafted since Yao retired. A 7-foot-1 center who lacked strength, Qi looked overwhelmed in 19 games with Yao’s old team before he returned home.
Fanbo Zeng practices at the Ultimate Fieldhouse, Tuesday, Oct. 19, 2021, in Walnut Creek, Calif. Zeng, 18, plays as a forward for the NBA G League Ignite.
Unlike Princepal Singh, who was on Ignite last season largely for the media attention he brought the NBA’s efforts in his native India, Zeng is a top prospect. With a 6-11 wingspan, soft touch around the rim, smooth shooting motion and impressive vertical leap, he was a four-star recruit at Windermere Prep outside Orlando before he flew back to China when the school shut down in March 2020 because of the pandemic.
Zeng’s dunks have received hundreds of thousands of views on YouTube. Ignite head coach Jason Hart has barely watched him practice with the team, but he saw enough from Zeng in individual workouts to reserve a significant rotation role for him.
“He’s extremely talented,” Hart said of Zeng, who arrived in Walnut Creek less than three weeks ago. “He’s a multi-skilled forward with an unbelievable shooting touch. He has an off-the-chart skill level. I’m very excited.”
NBA officials are, too. China has been a top priority for the league since at least 1987, when then-Commissioner David Stern offered to let China Central Television broadcast games for free. In ensuing decades, China blossomed into the NBA’s most important revenue source outside the U.S., with more than 200 employees in Shanghai, Beijing and Hong Kong.
This fruitful relationship plunged into crisis two years ago, when NBA Commissioner Adam Silver refused to fire then-Rockets general manager Daryl Morey after Morey tweeted in support of pro-democracy protesters in Hong Kong. By producing another Yao-level star, China would help ease any lingering tensions between it and the NBA.
Many Chinese people acknowledge that their country relied too long on Yao’s legacy, overlooking issues with a state sports system that hurt its basketball development.
Unlike the U.S., where players are weeded out in youth teams, high school leagues and colleges, China has athletic schools that recruit players as young as age 4. Officials long chose children based almost exclusively on size, but height doesn’t predict basketball greatness — especially in an era when the top professional leagues are trending toward a position-less style that emphasizes speed and skill.
At the Olympic qualifying tournament in Victoria, Canada, in July, the Chinese national men’s basketball team lost to Canada and Greece by a combined 55 points despite a distinct height advantage over both opponents. Chinese fans hope that Zeng, who attended high school stateside instead of continuing his youth program in Beijing, offers a model the country’s other top young players can follow.
Fanbo Zeng practices at the Ultimate Fieldhouse, Tuesday, Oct. 19, 2021, in Walnut Creek, Calif. Zeng, 18, plays as a forward for the NBA G League Ignite.
The only child of two former professional basketball players, Zeng grew up idolizing Yao in Harbin — a city in northeast China known more for winter tourism than sports. At age 11, he moved by himself more than 750 miles southwest to Beijing, where he shared a dorm room with a teammate and trained with the youth clubs of the Chinese Basketball Association’s Beijing Ducks.
After three years there, Zeng was among a small group of Chinese teenagers selected to attend the United States Basketball Academy — a program that allows Asian-born players to study English while acclimating to America’s grassroots system. For the next 12 months, Zeng learned the nuances of help-side defense and off-ball movement in a rural central Oregon gym that had a banner of his role model, Yao, hanging over it.
One of USBA’s directors connected Zeng with Windermere Prep, a school in Lake Butler, Fla., that houses about 100 Chinese boarding students. As a 15-year-old freshman, Zeng spoke little English, second-guessed his on-court decisions and struggled with opponents’ physicality.
But as the months passed, he began to feel more comfortable. Friends met with Zeng at a breakfast spot each Saturday morning to discuss classes, movies and basketball. When Zeng felt homesick, Windermere Prep head coach Brian Hoff consoled him.
“The pressure on him as a teenage kid is unlike anything that any of us have probably experienced,” Hoff said. “It’s a little bit unfair. But at the same time, Fanbo is a very mentally strong kid. Every time I talk to him, I encourage him to just continue working on his game and block out the noise.”
By Zeng’s sophomore year, he was one of Florida’s top players — a versatile forward who shot 47% from 3-point range, averaged 2.6 blocks per game and stockpiled offers from college basketball’s blueblood programs. When the pandemic forced Windermere Prep to shut down that spring, Zeng, like many of the Chinese boarders, headed home.
What was supposed to be a month-long visit became a year-and-a-half stay. Unable to fly back stateside because of travel restrictions, Zeng completed his high school coursework online, communicated with college coaches over email and trained with the Chinese national team.
Though he verbally committed to Gonzaga in November, he began to reconsider when assistant coach Tommy Lloyd, the Bulldogs’ primary recruiter for him, became Arizona’s head coach in the spring. Zeng’s agent contacted NBA G League President Shareef Abdur-Rahim, a former Cal and NBA forward who offered Zeng a six-figure contract to reclassify to the 2021 class and sign with G League Ignite.
Many NBA scouts believe it was the right move for Zeng — not just because he can better capitalize on his global appeal as a pro, but because he’ll have a better shot at significant playing time. Gonzaga has perhaps the most loaded frontcourt in college basketball, and it viewed Zeng as a three- or four-year project. Ignite coaches consider it their job, however, to showcase Zeng and give him a chance to get drafted next year.
For that to happen, he must add considerable muscle and excel against grown men in the G League — all while shouldering the expectations of NBA officials and the world’s most populous country.
“I can’t represent all of China,” Zeng said when asked how it feels to be China’s next great basketball hope. “It’s too big for me.”
Connor Letourneau is a San Francisco Chronicle staff writer. Email: [email protected]. Twitter: @Con_Chron
Connor Letourneau moved to the Golden State Warriors beat in September 2016 after a year covering Cal. Previously, he spent two years covering the Oregon State Beavers for The Oregonian. Letourneau is a University of Maryland alum who has interned for The Baltimore Sun and blogged for The New York Times. A Portland, Ore., native, he is interested in telling the stories that extend beyond the field or court.

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