Robot Industry Shines in China – OpenGov Asia – OpenGov Asia

The intelligent industry represented by robots is injecting new momentum into high-quality economic development and the global robot ecosystem is constantly improving in China. China also created an open platform to gather innovation resources, introduce new products and facilitate industrial cooperation. The robot industry needs to strengthen basic research and make technical breakthroughs to make more original innovations.
Secretary of China’s Leading Party Members Group called on to put enterprises at the dominant position of innovation and promote the integration of industries, universities and research agencies to better communicate science and create a sound social environment to boost the industry.
Chinese sci-tech and industrial communities should join hands with their global peers to develop intelligent industry and deepen innovative cooperation to make contributions to building a community with a shared future for mankind.
The robot industry is one of the major priorities in Beijing’s accelerating process to become an international sci-tech innovation centre.
– Mayor of Beijing
Beijing will give full play to its sci-tech advantages to provide support for the enterprises to carry out research, facilitate industrialisation and promote the coordinated development of robot enterprises with intelligent manufacturing.
The mayor of Beijing urged to gather all kinds of innovation elements to foster industrial champions and leading-position enterprises, establish joint platforms for innovation, cooperation and product test and verification, empower traditional industries with new modes and build highlands of robot innovation and application.
The Chinese government has attached great importance to boosting the high-quality development of the robot industry. The Ministry of Industry and Information Technology must implement the important instructions of the President of China and follow the deployment of the CPC Central Committee and the State Council to promote China’s robot industry from 4 perspectives: consolidating the industrial foundation, enhancing product supply, expanding application and optimising industrial ecology.
The exhibition displayed more than 500 new products from more than 110 enterprises and research agencies. The medical treatment robots and the application of brain-computer interface technologies highlighted the exhibition. Relevant experts, scholars and entrepreneurs both at home and abroad, together with representatives of international agencies participated in the event in a combination form of online and on-spot.
According to the International Federation of Robotics (IFR), China has had the most industrial robots in operation globally since 2016. By 2020, China is expected to produce 150,000 industrial robot units and have 950,300 industrial robots in operation.
China’s robotics industry is large, but still has significant room for development. The Chinese government has recognised as much in its Made in China 2025 (MIC 2025) industrial policy, which identifies the robotics industry as a strategically important sector. This designation creates both opportunities and challenges for foreign investors.
MIC 2025 starts by listing the robotics industry, along with artificial intelligence and automation, as one of the priority sectors for high-end development to push forward the transformation and upgrading of the manufacturing industry.
China has been utilising robots in various fields, including healthcare with the development of vascular interventional surgical robots. As reported by OpenGov Asia, Chinese researchers from the Beijing Institute of Technology have cooperated with Beijing Tiantan Hospital and other units to research core technology optimisation and special consumables of vascular interventional surgery robots. The surgery robot has become the interventional robot product with the fastest research and development progress in China.
With the support of the project of the National Key R&D Programme of China “Industrialisation Research and Application of Minimally Invasive Vascular Interventional Surgery Robot”, the development of the robot was fully completed. At present, the surgical robot, after further technological upgrades, has taken the lead in entering the clinical trial stage registered by the NMPA (National Medical Products Administration), and 123 clinical trial cases have been completed.
State-run carrier Viettel has successfully researched, tested, and established a 5G data transmission speed of more than 4.7Gb per second. This speed is 40 times higher than the 4G speed and more than two times the existing 5G speed, making Viettel one of the fastest 5G telecom networks in Asia.
According to a press release, the result confirms the outstanding capacity of the 5G ultra-short wave (mmWave) technology that Viettel is deploying in Vietnam. A 5G network with super high speeds is the foundation for building smart factories, agriculture, cities, healthcare, and education. To achieve a record data transmission speed, the research team of Viettel and a few other private players used the world’s most advanced E-UTRA New Radio Dual Connectivity (EN-DC) technology to increase speed and extend 5G coverage.
In the process of implementing technical solutions at Viettel Innovation Lab, Viettel used private player radio equipment and mobile devices using a state-of-the-art processor. Viettel has been a pioneer in deploying 5G in Vietnam and the only network operator in the world with the capacity to research and develop 5G equipment. The CEO of Viettel Networks stated that this breakthrough in speed helps increase the efficiency of Viettel’s 5G network. The organisation will continue to promote this technology so that people, businesses, governments, and society at large can experience the distinct benefits of 5G in particular and 4.0 technology in general.
An industry expert noted that this is an easy-to-install solution that promises to accelerate widespread 5G deployment in high-density urban areas with many preeminent features, ensuring the best user experience. The results of the trial confirm that Viettel’s 5G infrastructure is ready to deliver outstanding 5G services and experiences and promote the vision of digitising industries in Vietnam. This achievement enables large capacity, multi-Gigabit speeds, and low latency in solutions for individuals and businesses. The country has taken another important step in enabling Vietnamese people to access high-speed 5G equipment anytime, anywhere.
Earlier in July, Hanoi authorities announced a new postal telecommunications infrastructure development plan for 2025 with a vision for 2030. It aims to serve the city’s digital transformation programme. It defines postal infrastructure as an important factor of the digital economy, which contributes to promoting the development of a digital government and digital society.
Under the plan, the city targets 100% of communes to establish a post office with staff; all households register digital addresses; 4G/5G services and smartphones universalised, and fibre-optic broadband covering 80% of local households and every commune. Meanwhile, 80% of local industrial parks, high-tech parks and higher education facilities, hospitals, and public departments will be covered by 5G services. Also, about 95% of total households in Hanoi are expected to own and use at least one smartphone by 2025.
As OpenGov Asia reported, the city will prioritise high-quality broadband telecommunication infrastructure in high-tech parks, concentrated IT parks, industrial parks, export processing zones, R&D and innovation centres, schools, state agencies, hospitals, and tourism sites. Hanoi will also develop free WiFi networks in all tourist sites across the city. Apart from this, the city will speed up activities to promote the universalisation of smartphones and help local residents to access digital services easily. To this end, the municipal People’s Committee is encouraging economic sectors to build postal and telecommunication infrastructure systems and diversify telecommunication services.
The government of the Philippines has made e-commerce and electronic payment methods a priority in efforts to boost both financial and digital inclusion throughout the country. In line with this, the Bangko Sentral ng Pilipinas (BSP) recently reaffirmed that they will continue to promote the digitalisation of financial products and services in the country even after the restrictions forced by the pandemic are lifted.
Last year, the central bank released the Digital Payments Transformation Roadmap (DPTR) for 2020-2023. Under the DPTR, the BSP aims to increase customer preference for digital payments by converting 50% of total retail payments to digital form and increasing the number of financially included Filipino adults to 70% by onboarding them to the formal financial system via payment or transaction accounts.
In an article, OpenGov Asia stated that fintech applications and technologies are constantly evolving, allowing more Filipinos to conduct financial transactions without the need for a bank account. Fintech products, such as e-wallets, allow users to transfer money digitally and build credit, making it easier for them to borrow funds in the future.
Moreover, the proposed framework for open banking by the Bangko Sentral ng Pilipinas (BSP) aims to benefit MSMEs by encouraging financial inclusion and making the deployment of innovative financial services faster and easier. With the right infrastructure, banks and fintech companies can create more cost-effective, personalised, and seamless solutions for MSMEs, facilitating distribution, data sharing, and payment enablement.
All these initiatives strive to assist BSP-supervised financial institutions’ digital transformation programmes, including fintech players, while also promoting sound risk technology and cyber risk management.
Earlier this year, the central bank and the country’s other financial regulators agreed to develop a unified monitoring and supervision scheme for the local fintech industry that does not stifle these firms’ innovative and creative ideas. To that end, a memorandum of understanding on the establishment of a cooperative oversight framework on fintech innovation was signed under the auspices of the multiagency Financial Sector Forum.
The BSP asserted that the roadmap intends to transform the country into a cash-lite society. During the pandemic, the use of digital payments reduced the need for mobility and helped to avoid health risks associated with face-to-face and over-the-counter financial transactions. The BSP stated that in the first seven months of 2021, the value of transactions made through its local E-wallets increased by more than 180%, and another by more than 80%.
Both Philippines’ leading E-wallets are automated clearing houses under the National Retail Payment System. One of the leading E-wallet platforms is a batch electronic fund transfer (EFT) that can be thought of as an electronic alternative to the paper-based check system, whereas the other leading E-wallet is a real-time, low-value EFT for transactions up to P50,000 that is useful for e-commerce.
With the rate of digitisation increasing in the Philippines, e-commerce merchants must capitalise on this shift in consumer attitudes by offering a variety of payment options along with appealing offers to attract the attention of a wide range of users. Offering multiple payment methods, including cash, and collaborating with local partners who have a thorough understanding of the Philippine market (not just retail and payments, but also logistics fulfilment and last-mile deliveries), could assist in transforming the Philippines into an e-commerce territory, opening more opportunities in the rest of Southeast Asia.
The Indian Institute of Science in Bangalore (IISc), in collaboration with a private player, announced it would establish a state-of-the-art artificial intelligence and machine learning (AI/ML) centre at the IISc campus. Spread across approximately 140,000 square feet, the centre will offer Bachelor’s, Master’s, and short-term courses in areas AI/ML, deep learning, fintech, reinforcement learning, image processing, and computer vision.
The centre will also promote research and innovation in AI/ML and develop the talent pool from across the country to provide cutting-edge solutions to meet the industry’s emerging and future requirements. According to a statement, as IISc continues to deliver on its mandate to provide advanced scientific and technological research and education, its partnerships with forward-thinking institutions will help it scale up substantially and position India as a deep tech innovation hub.
As per a recent report, the global AI market size is expected to gain momentum and reach US$360.36 billion by 2028 while exhibiting a CAGR of 33.6% between 2021 to 2028. AI has become immensely popular, and industries across the globe are rapidly incorporating it into their processes to improve business operations and customer experience. The Indian government is developing and implementing several AI-driven initiatives in education, healthcare, agriculture, and finance. Educational institutes and government agencies are launching centres and offering courses in emerging technology to help build a skilled workforce.
For instance, earlier this year, India’s Ministry of Finance entered a strategic partnership with a tech giant to build a Centre of Excellence in AI and emerging technologies at the Arun Jaitley National Institute of Financial Management (AJNIFM). The centre will serve as a central body for research, AI scenario envisioning, and technology-led innovation. The two sides would jointly explore use cases of emerging technologies in finance and related areas, across central and state ministries and public sector enterprises. Also, public sector officials would be trained on the application of emerging technologies in finance management to address potential risks like money laundering, the use of machine learning models for decision making, and the role of responsible tech in finance, among others. As OpenGov Asia had reported, the collaboration would explore the role of cloud, AI, and emerging technologies in transforming and shaping the future of public finance management in India.
More recently, the Indian Institute of Technology in Madras (IIT-Madras), in association with a semiconductor manufacturing company, is offering a free workshop on AI and high-performance computing technology in semiconductor manufacturing. The workshop is being offered under the “National Supercomputing Mission Industry Talks” series. The workshop is free; however, it is mandatory for interested participants to register before attending the workshop online.
According to a news report, the workshop will be conducted from 27 September to 1 October every day for one hour, and the e-meeting details will be sent only to registered participants. The workshop is open to all interested participants, and the following topics will be covered by industry experts over five days:
Singapore Land Authority (SLA) has released a fully integrated 3D version of OneMap, Singapore’s authoritative national map. The tool is the certified national map of Singapore which contains the latest and most comprehensive information on Singapore’s landscape. A product of a collaboration between several government agencies, the map’s services are free to access.
The application, OneMap3D, was unveiled at the Singapore Geospatial Festival 2021, where SLA also signed separate memorandums of understanding (MOU) with the country’s logistics and real estate agencies to expand the industry’s use of OneMap.
The latest was created by converting the original format to 3D using open-source 3D geospatial technology and 3D city modelling. Initially, OneMap was first released in 2010, followed by an improved version in 2017 in 2D that included features such as real-time traffic data and an Application Programming Interface (API) for app developers.
It is built on our commitment to enhance our country’s geospatial capabilities and to provide new geospatial solutions for businesses, government and the wider public.
– Singapore’s culture, community and youth minister
OneMap is the country’s digital map service, and it is constantly updated with information from government agencies, such as where citizens can pick up a free face mask. Singapore’s Civil Defence Force also used OneMap to create MyResponder, an app that alerts all trained first responders to cardiac arrests in the area. The new OneMap3D upgrade will allow citizens to navigate through a neighbourhood in the first-person view, simulating what a route would look like in person.
As reported by OpenGov Asia, Geospatial Technology involves the use of technology for collecting and utilising geographic information. Some of these technologies include Geographic Information System (GIS), GPS, remote sensing, and geofencing.
On the prevalence of the use of geospatial information in Singapore, organisations such as Grab manipulate this data to be able to match drivers with passengers, in real-time. There is already an everyday use of geospatial technology with the likes of GPS for navigating around. It provides location-based services such as:
SLA Chief Executive says the MOUs with the logistics and real estate agencies are part of SLA’s efforts to collaborate with industry leaders to promote growth and opportunities through geospatial solutions.
SLA’s MOU with the property or real estate company in the real estate space will result in the development of new feature data collection and customised Application Programming Interface (API) to improve the property company’s applications and OneMap geospatial information. As per the company’s CEO, the collaboration has the potential to be a “game-changer” in the real estate industry.
In contrast, the parties will collaborate on geospatial co-innovations to improve hyperlocal and granular data at the street level for last-mile delivery under SLA’s MOU with Singapore’s logistics company. “We are delighted to be SLA’s first express logistics partner for GeoWorks,” says the CEO of the logistics firm.
He went on to say that by having the company’s drivers contribute pictorial information to enable OneMap’s accuracy and data volume, the company could potentially set a new industry operational standard by improving the entire last-mile delivery process.
The SLA and homegrown robotics and automation solution company MOU will see the trial of automated data capture with robots, limiting the time and effort from manual data capture, to develop geospatial innovation in the area of robotics and automation solutions. This collaboration will also allow SLA and the company to develop standards for robotics-ready maps and map information interoperability for compatibility across multiple platforms.
Self-driving cars are likely to be the future of transportation, but safety concerns are hurdles that researchers have to overcome to make fully autonomous vehicles become a reality. To accelerate that timeline, U.S. researchers have developed the first set of “certifiable perception” algorithms, which could help protect the next generation of self-driving vehicles — and the vehicles they share the road with. When robots sense their surroundings, they must use algorithms to make estimations about the environment and their location.
These perception algorithms are designed to be fast, with little guarantee of whether the robot has succeeded in gaining a correct understanding of its surroundings. This is one of the biggest existing problems. Our lab is working to design certified algorithms that can tell you if these estimations are correct.
– Lead researcher
Robot perception begins with the robot capturing an image, such as a self-driving car taking a snapshot of an approaching car. The image goes through a machine-learning system called a neural network, which generates key points within the image about the approaching car’s mirrors, wheels, doors.
From there, lines are drawn that seek to trace the detected key points on the 2D car image to the labelled 3D key points in a 3D car model. The researchers must then solve an optimisation problem to rotate and translate the 3D model to align with the key points on the image. This 3D model will help the robot understand the real-world environment.
Each traced line must be analysed to see if it has created a correct match. Since many key points could be matched incorrectly. The team’s algorithm smooths the non-convex problem to become convex and finds successful matches. If the match is not correct, their algorithm will know how to continue trying until it finds the best solution, known as the global minimum. A certificate is given when there are no better solutions.
These certifiable algorithms have a huge potential impact because tools like self-driving cars must be robust and trustworthy. The goal is to make it so a driver will receive an alert to take over the steering wheel if the perception system has failed.
The 3D model gets morphed to match the 2D image by undergoing a linear combination of previously identified vehicles. For example, the model could shift from being an Audi to a Hyundai as it registers the correct build of the actual car. Identifying the approaching car’s dimensions is key to preventing collisions.
The lead researcher stated that to achieve trustworthy autonomy, it is time to embrace a diverse set of tools to design the next generation of safe perception algorithms. There must always be a failsafe since no human-made system can be perfect. The safety precautions for self-driving cars will take the power of both rigorous theory and computation to revolutionise what it can be successfully unveiled to the public.
U.S. researchers have been developing robotic technologies for various purposes, including to help people with disabilities. As reported by OpenGov Asia, U.S. Researchers have now developed an alternative approach that they believe could offer much more precise control of prosthetic limbs. After inserting small magnetic beads into muscle tissue within the amputated residuum, they can precisely measure the length of a muscle as it contracts, and this feedback can be relayed to a bionic prosthesis within milliseconds.
In a new study appearing today in Science Robotics, the researchers tested their new strategy, called magnetomicrometry (MM), and showed that it can provide fast and accurate muscle measurements in animals. They hope to test the approach in people with amputation within the next few years.
Western Australia’s Main Roads has completed the migration of its customer relationship management (CRM) system into the cloud in collaboration with an American multinational technology corporation. The government agency has transitioned CONNECT, a Dynamics-powered CRM suite by the company, to the cloud as part of a nine-month project.
The project, supported by ASG and WithPrecision, is aimed at modernising the legacy system and providing enhanced support for its network operations centre. The new cloud-based CONNECT platform is being integrated with Main Roads’ raft of legacy software, including its Oracle-based road data application and its record-keeping systems.
Main Roads is planning to create an Azure Data Lake to store data from different systems. To enhance its data and analytics capabilities, the agency also plans to make more use of Microsoft’s Power Platform to turn the stored data into actionable insights.
The platform has been customised to support the agency’s 24/7 Customer Information Centre by allowing staff to record calls as a customer activity or convert them into a case or fault report. Activities, cases or fault reports can also be linked to customised Project pages providing a centralised view of all customer interactions related to road projects across WA.
Main Roads CRM System Manager stated that the new platform has been well received by users. He noted that people very quickly could see the advantage of having a centralised customer system and start building a more holistic view of our customers. It gives the team a real-time view of what’s going on within infrastructure delivery projects which they never had before.
OpenGov Asia recently reported that Transport for NSW is hoping that aggregated data collected by a Dutch consumer electronics company and LiDAR systems might provide it with more timely insight into conditions and hazards on the state’s road network. The agency, in collaboration with iMOVE Cooperative Research Centre (CRC), currently relies on videos taken by crews for safety assessments, from which certain road attributes are extracted.
However, TfNSW wants to speed up the process, and has embarked on a project that will “convert raw data… into an international standard five-star rating system”. The project will deliver 20,000 km of road attributes in NSW using TomTom’s MN-R map data, as well as prove feature extraction techniques and machine learning for LiDAR data.
MN-R is the model that the consumer electronics company uses to keep its mapping data up-to-date. It combines several layers of data collection techniques, including from the use of its navigation systems and from sensors.
In addition to understanding road conditions and hazards, TfNSW hopes the project could also lead to the development of predictive algorithms around injuries and fatalities in the future. The project will feed into a global ‘AiRAP’ initiative from a non-profit roads rating agency, the International Road Assessment Programme (iRAP).
TfNSW is also working with the University of Technology Sydney and geospatial data experts an NSW software company on the project. The local company has previously partnered with the consumer electronics company to extract more than 50 road assets and safety features such as road markings, safety barriers and trees from LiDAR data.
The IRAP global innovation manager, who is overseeing the project, said AI had the “potential to reduce costs and increase the frequency and accuracy of data”. She noted that making faster and more affordable data collection possible means that safety assessments can be done on an annual basis across the whole road network.
The global road safety market size was valued at US$2.88 billion in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 12.4% from 2021 to 2028. During the COVID-19 pandemic, road fatalities witnessed a sharp decline.
The Ministry of Agriculture signed five memorandums of understanding (MoUs) with five tech giants. Under the collaborations, the private players will conduct pilot projects to integrate digital technology and other best practices in the agricultural sector.
According to a news report, these MoUs are a part of the digital agriculture mission that was initiated for 2021-25 by the government to integrate emerging technology such as artificial intelligence (AI), blockchain, remote sensing and GIS technology and the use of drones and robots, etc. Establishing a digital ecosystem of agriculture needs to take a long-term view of aspects like interoperability, data governance, data quality, data standards, security, and privacy, besides promoting innovation. A significant requirement is the adoption of a decentralised, federated architecture that assures autonomy to the service providers and all other actors and ensures interoperability at the same time.
To support these projects, the ministry is creating a federated farmers database that will be linked to farmers’ land records from across the country and a unique farmer ID will be created. These technologies will support farmers to make informed decisions on suitable crops to grow, types of seeds to use, and the best practices for maximum yields. The agriculture supply chain players can plan their procurement and logistics on precise and timely information. Farmers can make informed decisions about whether to sell or store their produce and when and where and what price to sell, the report said.
Further, under the unified database for all farmers, users can access the information of all benefits and supports of various schemes of the central and state governments. So far, the database is ready with details of around 55 million farmers. Any attempt to transform the agriculture sector needs to imbibe an ecosystem thinking and a digital ecosystem. The agriculture value chain extends from crop selection to crop management and the market; it involves public and private players in agricultural inputs and services and also logistics.
The country has been using technology to improve crop yield and double farmer incomes. In July, researchers at the Indian Institute of Technology in Mandi (IIT-Mandi) and the Central Potato Research Institute (CPRI) in Shimla developed an AI solution that can detect diseased parts of potato crop using photographs of its leaves. As OpenGov Asia had reported, blight is a common disease of the potato plant. It leads to the rotting of the plant. If left undetected and unchecked, blight could destroy the entire crop within a week under conducive conditions.
IIT-Mandi’s computational tool can detect blight in potato leaf images. The model is built using an AI tool called mask region-based convolutional neural network architecture and can accurately highlight the diseased portions of the leaf amid a complex background of plant and soil matter. In India, as with most developing countries, the detection and identification of blight are performed manually by trained personnel who scout the field and visually inspect potato foliage. This process, as expected, is tedious and often impractical, especially for remote areas, because it requires the expertise of a horticultural specialist who may not be physically accessible.
Automated disease detection can help in this regard and given the extensive proliferation of mobile phones across the country, the smartphone could be a useful tool, according to a researcher on the team. The advanced HD cameras, better computing power, and communication avenues offered by smartphones offer a promising platform for automated disease detection in crops.

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Allergies to mRNA-based COVID-19 vaccines rare, generally mild, Stanford study finds – EurekAlert

Stanford Medicine
Allergic reactions to the new mRNA-based COVID-19 vaccines are rare, typically mild and treatable, and they should not deter people from becoming vaccinated, according to research from the Stanford University School of Medicine.      
The findings will be published online Sept. 17 in JAMA Network Open.     
“We wanted to understand the spectrum of allergies to the new vaccines and understand what was causing them,” said the study’s senior author, Kari Nadeau, MD, PhD, the Naddisy Foundation Professor in Pediatric Food Allergy, Immunology, and Asthma.    
The study analyzed 22 potential allergic reactions to the first 39,000 doses of Pfizer and Moderna COVID-19 vaccines given to health care providers at Stanford soon after the vaccines received emergency use authorization from the Food and Drug Administration.       
Most of those in the study who developed reactions were allergic to an ingredient that helps stabilize the COVID-19 vaccines; they did not show allergies to the vaccine components that provide immunity to the SARS-CoV-2 virus. Furthermore, these allergic reactions occurred via an indirect activation of allergy pathways, which makes them easier to mitigate than many allergic responses.        
“It’s nice to know these reactions are manageable,” said Nadeau, who directs the Sean N. Parker Center for Allergy and Asthma Research at Stanford. “Having an allergic reaction to these new vaccines is uncommon, and if it does happen, there’s a way to manage it.”      
The study’s lead author is former postdoctoral scholar Christopher Warren, PhD, now an assistant professor at Northwestern University Feinberg School of Medicine.      
The research also suggests how vaccine manufacturers can reformulate the vaccines to make them less likely to trigger allergic responses, Nadeau said.      
Delivery of protein-making instructions     
The mRNA-based COVID-19 vaccines provide immunity via small pieces of messenger RNA that encode molecular instructions for making proteins. Because the mRNA in the vaccines is fragile, it is encased in bubbles of lipids — fatty substances — and sugars for stability. When the vaccine is injected into someone’s arm, the mRNA can enter nearby muscle and immune cells, which then manufacture noninfectious proteins resembling those on the surface of the SARS-CoV-2 virus. The proteins trigger an immune response that allows the person’s immune system to recognize and defend against the virus.       
Estimated rates of severe vaccine-related anaphylaxis — allergic reactions bad enough to require hospitalization — are 4.7 and 2.5 cases per million doses for the Pfizer and Moderna vaccines, respectively, according to the federal Vaccine Adverse Event Reporting System. However, the federal system doesn’t capture all allergic reactions to vaccines, tending to miss those that are mild or moderate.      
For a more complete understanding of allergic reactions to the new vaccines — how common they are, as well as how severe — the research team examined the medical records of health care workers who received 38,895 doses of mRNA-based COVID-19 vaccines at Stanford Medicine between Dec. 18, 2020, and Jan. 26, 2021. The vaccinations included 31,635 doses of the Pfizer vaccine and 7,260 doses of the Moderna vaccine.      
The researchers searched vaccine recipients’ medical records for treatment of allergic reactions and identified which reactions were linked to the vaccines. Twenty-two recipients, 20 of them women, had possible allergic reactions, meaning specific symptoms starting within three hours of receiving the shots. The researchers looked for the following symptoms in recipients’ medical records: hives; swelling of the mouth, lips, tongue or throat; shortness of breath, wheezing or chest tightness; or changes in blood pressure or loss of consciousness. Only 17 of the 22 recipients had reactions that met diagnostic criteria for an allergic reaction. Three recipients received epinephrine, usually given for stronger anaphylaxis. All 22 fully recovered.      
Of the 22 recipients, 15 had physician-documented histories of prior allergic reactions, including 10 to antibiotics, nine to foods and eight to nonantibiotic medications. (Some recipients had more than one type of allergy.)      
The researchers performed follow-up laboratory testing on 11 individuals to determine what type of allergic reaction they had, as well as what triggered their allergy: Was it one of the inert sugar or lipid ingredients in the bubble, or something else in the vaccine?       
The study participants underwent skin-prick tests, in which a clinician injected small amounts of potential allergens — the lipids, sugars (polyethylene glycol or polysorbates) or entire vaccine — into the skin. Skin-prick testing detects allergic reactions mediated by a form of antibody known as immunoglobin E, or IgE; these reactions are generally associated with the severest allergies.       
None of the recipients reacted on skin-prick tests to the inert ingredients in the vaccines, and just one recipient’s skin reacted to the whole COVID-19 vaccine. Follow-up blood tests showed that the vaccine recipients did not have significant levels of IgE antibodies against the vaccine ingredients.      
Since the skin tests did not explain the mechanism of recipients’ allergic reactions, the investigators proceeded to another type of diagnostic test. Vaccine recipients provided blood samples for tests of allergic activation of immune cells known as basophils. The blood samples from 10 of the 11 participants showed a reaction to the inert ingredient polyethylene glycol (PEG), which is used in both the Pfizer and Moderna vaccines. In addition, all 11 recipients had basophil activation in response to the whole mRNA vaccine when it was mixed with their own basophils.      
All 11 subjects had high levels of IgG antibodies against PEG in their blood; IgG antibodies help activate basophils under some conditions, and this finding suggests the individuals were likely sensitive to PEG before receiving their vaccines.     
“What’s important is what we didn’t find, as much as what we did find,” Nadeau said. “It does not seem that the mRNA itself causes the allergic reactions.”     
In addition, the data suggest that reactions to the COVID-19 vaccines were generally not the most severe form of allergic reaction, which is good news in terms of vaccine safety, she said. Allergic reactions mediated by IgG and basophils can be managed with antihistamines, fluids, corticosteroids and close observation, meaning that many individuals who have had a reaction to their first vaccine dose can safely receive a second dose under medical supervision.      
PEG is widely used as a stabilizer in household products, cosmetics and medications, with women more likely to be exposed to large quantities of the substance, possibly explaining why more vaccine allergies have been seen among women. (Repeated exposures to a substance can sometimes sensitize the immune system and provoke allergies.) Because most reactions were to PEG rather than the vaccine’s active ingredients, it is likely that vaccine manufacturers can reformulate the vaccines with different stabilizers that are less likely to cause allergies, Nadeau said.      
###
The study’s other Stanford authors are research assistants Theo Snow, Alexandra Lee, Mihir Shah, Eric Smith, Evan Do and Iris Chang; Andra Blomkalns, MD, professor of emergency medicine; Brooke Betts, PharmD, clinical pharmacist; medical student Anthony Buzzanco; graduate student Joseph Gonzalez; Sharon Chinthrajah, MD, associate professor of medicine and of pediatrics; lab manager Diane Dunham; Grace Lee, MD, professor of pediatrics; Ruth O’Hara, MD, PhD, dean of research and professor of psychiatry and behavioral sciences; Helen Park, PharmD, clinical pharmacist at the Veterans’ Affairs Palo Alto Health Care System; Lisa Schilling, RN, MPH, vice president of quality, safety and clinical effectiveness and chief quality officer with Stanford Health Care; Sayantani Sindher, MD, clinical associate professor of medicine and of pediatrics; Deepak Sisodiya, PharmD, administrative director of pharmacy services at Stanford Health Care; Mindy Tsai, DMSc, senior research scientist in pathology; and Stephen Galli, MD, professor of pathology and of microbiology and immunology.     
Nadeau is a member of the Stanford Institute for Immunology, Transplantation and Infection; senior fellow at the Stanford Woods Institute for the Environment; a fellow at the Stanford Center for Innovation and Global Health; and member of the Bill Lane Center for the American West at Stanford. Nadeau and Galli are members of Stanford Bio-X. Nadeau, O’Hara and Galli are members of the Stanford Cardiovascular Institute. Nadeau and O’Hara are members of the Wu Tsai Neurosciences Institute at Stanford. O’Hara, Nadeau, Chinthrajah, Grace Lee, Sindher and Galli are members of the Stanford Maternal and Child Health Research Institute. Galli is a member of the Stanford Cancer Institute.     
Researchers from the Swiss Institute of Allergy and Asthma Research at the University of Zurich; the Department of National Heart and Lung Institute at Imperial College London; and the Centre in Allergic Mechanisms of Asthma, London, also contributed to this research.      
The research was supported by the Asthma and Allergic Diseases Cooperative Research Centers (grant U19AI104209), the National Institutes of Health (grant R01AI140134), the National Institute of Allergy and Infectious Disease SARS Vaccine study (grant UM1AI10956508), the Parker Foundation, the Crown Foundation and the Sunshine Foundation. 
Media contacts: Lisa Kim at (650) 723-6696 ([email protected]); Erin Digitale at (650) 724-9175 ([email protected]
The Stanford University School of Medicine consistently ranks among the nation’s top medical schools, integrating research, medical education, patient care and community service. For more news about the school, please visit http://med.stanford.edu/school.html. The medical school is part of Stanford Medicine, which includes Stanford Health Care and Stanford Children’s Health. For information about all three, please visit http://med.stanford.edu.
JAMA Network Open
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No seed spitting contest but plenty of watermelons at Newberry Festival – Gainesville Sun

A concession was made to COVID-19 and the fruit of honor had to be hauled in from Belle Glade but Saturday’s Newberry Watermelon Festival was a taste of freedom for a crowd seeking normalcy.
The festival was the only annual event held in Alachua County last year as the coronavirus took hold and may yet be the only one this year as these things take planning. This was the 76th straight year of the event.
“We’re not doing the seed spitting contest because I don’t think it’s prudent yet to do that even though we don’t have the mask mandate anymore,” festival President Kathryn Thomas said. “We have about 75 vendors. We had the parade, the Watermelon Queen, a dog pageant, a hog-calling contest, eating contests, a watermelon roll — we’ve got a lot.”
They also had a lot of watermelons. The festival was too early for the ripening of the local crop, so big boxes full of the juicy treat were brought in from Belle Glade.
A large tent erected by the Newberry First United Methodist Church was where the melons were sliced and eaten — plenty of people were sneaking seconds.
Several machetes were laid out on a table and Darryl Bowden, with deftness and muscle, used one to expertly hack through the rind.
“This is my first year chopping for the church but I’ve been in Newberry all my life,” Bowden said. “I’m just trying not to chop all my fingers.”
The Rev. Karen Burris, pastor of the church, said the watermelon was especially sweet and many festival patrons agreed.
But people can’t stroll around a festival on watermelon alone. Newberry’s had all the usual fair food to keep up the energy.
One booth, however, stood out. It’s not every festival that has a vendor of lobster tacos and bisque; ceviche with shrimp, scallops and grouper and steak bites.
Welcome to Le Jardin on the food block, nestled between the funnel cake and gelato trucks.
The festival for the past several years has been held around the town square of Country Way, a mixed-use development on U.S. 27 south of downtown Newberry that is still being built out.
This year’s festival had the added bonus of happening just days after the Centers for Disease Control announcement that people vaccinated for COVID-19 could safely go most places — especially outdoors — without face masks.
The move provided hope that the nation has weathered the worst of the pandemic.
“It’s a wonderful day, a beautiful day for people to come outside and get back together,” Newberry Mayor Jordan Marlowe said.

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Protein Kinase C Theta Market Growth Set to Surge Significantly during 2021 – 2027| AbbVie Inc, Astellas Pharma Inc, Celgene Corp, CompleGen Inc – Stillwater Current – Stillwater Current

protein kinase C-theta (PKCtheta) in the immune system since this Ca2+-independent PKC isotype was isolated as an enzyme that is highly expressed in T lymphocytes and in muscle cells.
Biochemical and genetic approaches revealed that, while dispensable for T-cell development, PKCtheta is required for the activation of mature T cells and for interleukin (IL)-2 production.
This deficiency results from impaired receptor-induced stimulation of the transcription factors AP-1 and NF-kappaB. PKCtheta integrates T-cell receptor (TCR)/CD28 costimulatory signals, which are essential for productive T-cell activation and, most likely, for prevention of T-cell anergy.
A unique property of PKCtheta is its highly selective recruitment to the central supramolecular activation complex (cSMAC) region of the immunological synapse (IS) in antigen-stimulated T cells.
Key Players
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Morrison County Deputies Recover Property Reported Stolen in 2020 – WJON News

MOTLEY – Authorities in Morrison County recovered property reported stolen last fall.
The Morrison County Sheriff's Office says deputies carried out a search warrant at a home just off Highway 10 in Scandia Valley Township south of Motley on Wednesday.
During the search, authorities found two enclosed trailers filled with items that were reported stolen in a burglary in November 2020. Authorities say the trailers and the items inside have an estimated value of more than $30,000.
Deputies questioned 40-year-old Derek Holmberg of Motley, who they say admitted his involvement in the burglary. He was arrested and awaits formal charges in the incident.

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Alamosa News | The future of Alamosa – Valley Courier

Saturday, September 18, 2021
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By: Stephen Jiron – Updated: 4 days ago
Posted Sep 14, 2021
ALAMOSA — There is a conundrum that follows a chicken and egg path in some governments. Who will make the first move with regard to progress. Government asks why they should make financial obligations when the private sector doesn’t care for their businesses. And when the private sector gets no help with progress they do the reverse ask. Well, government isn’t helping why should we make the effort.
Alamosa City Manager Heather Brooks spoke for city council stating that there is no such conundrum in Alamosa, “We’re doing our part, and we know people will start jumping on board to do their part.”
With Alamosa taking a big step in progressing towards a finalized downtown plan last month, it is becoming apparent that business owners are on board, “We’ve got more people doing façade grants than we ever have,” says Brooks. Façade Grants are meant to encourage property owners and tenants of buildings to make exterior improvements to help revitalize the area and attract customers to shop, dine and, in general, do business.
“We have next to no vacancies on storefronts facing downtown. And some of those decisions to do their business was because they knew we were doing this plan. And they were excited about this plan,” says Brooks.
Since having won the Governor’s Award for Downtown Excellence, the design plan for Downtown Alamosa is beginning to take shape. The latest step in what is hopefully a fruitful journey was taken with narrowing three blocks of downtown. Which has been met with something of a mixed reaction. Before that, Alamosa took the opportunity presented by funding from CDOT, CHFA and DOLA, as well as money from the CARES Act, which was given to municipalities and allowed Alamosa to kill two birds with one stone. The parklets make outdoor dining a reality for COVID compliance as well as satisfy an existing part of the downtown plan.
While many parts of the plan remain unfunded, Alamosa will not be staying stagnant. Which begs the question, what is next. There are some rather tantalizing features in the Downtown Plan but what are improvements can we expect to see soon.
The city will be looking to pick up some low-hanging fruit to keep the ball moving. One upcoming project is alleyway activations. The first two of which are slated as Fourth and State behind the incoming Altitude Appliance and Sixth Street between Walsh and May Was. Both of which will be expressing an expansion of the public realm as well as advertising for downtown.
“We want this to be vibrant, so people are like, ‘hey if that alley is that cool, let’s go downtown and see what’s going on,’” says Baird.
Vibrance and attraction will be achieved using simple facelifts in the form of murals and overhead lighting as well as overall trash cleanup and amenities including moveable seating and planters.
The city is being sure also not to bite off more than they can chew. Price quotes for Alley Activation have been done individually meaning the projects won’t bunch up and become insurmountable.
Still, portions of the more attainable parts of the plan will require grants.
“We used to write grant applications that were so complicated that the only people who used to apply for them were Aspen and Vail because they have dedicated grant writers,” says Alamosa Development Services Director Rachel Baird “In the old days, we never had a chance with those and now we do.”
A financially aggressive Alamosa is made possible by the creation of the Development Services Director position. Now Rachel handles developmental services and grant-writing putting Alamosa on the path to accomplishing their downtown goals with flexibility, not having to redirect money from other city projects into downtown.
“It’s going to go out, it’s going to be spent. It either comes here or it doesn’t… we either bring it to our community or we let it go to other communities,” says Brooks of dedicated grant money.
Said grants are entirely dedicated to certain uses, so when Alamosa collects downtown grants from the state they are specific, and cannot be used for anything other than their intended purpose, a built-in measure to prevent misuse.
Similar beautification will be carried over to San Juan between the SLV Brew Pub and Woody’s for a designated Festival Street. Since San Juan is a city road, Alamosa will have the availability to beautify using overhead string lights and banners. Also in the plan for Festival Street are removable bollards at the Main and Fourth intersections, allowing for temporary street closures for events. Plenty is in play for Festival Street, including a painted street and maybe down the road integrated utilities like power outlets and water connections to support events and vendors on the street.
Wayfinding will be receiving a facelift in Alamosa’s downtown as well. The City is partnering with the marketing board, Alamosa Convention and Visitors Bureau, to update wayfinding signage in the downtown in early 2022.
Getting into the thought process Baird credits traffic engineers Fox Tuttle with constructive insight, “They literally stopped us saying, ‘you know that you can’t read this going 25 miles per hour, the print is too small.’ There are set standards for how big your print should be based on how fast a motorist is traveling. ”
Though Colorado law is pedestrians are granted right of way, the City will be taking steps to ensure downtown safety with the addition of pedestrian crossing signs that flash yellow to encourage a friendlier and safer traffic pedestrian exchange. Crossing signs will be going up on San Juan at both the Sixth and Main street intersections, and Hunt street where it intersects with Sixth and Main. Which will grant dedicated pedestrian crossing on every road downtown.
Leading to something that could be in the 5-year plan, the Hunt Cultural Trail. Hunt street offers another opportunity for the City to potentially draw a line between form and function. As Hunt street deteriorates  Alamosa can seek a Community Development Block Grant (CDBG) to both repair a street in need and also possibly add the necessary streetscape to bring the Cultural Trail in line with the Downtown Plan. The plan includes everything from permanent seating to botanical accents and perhaps further down the road accented paving and historic statues acknowledging Alamosan history. A fully realized Cultural Trail could serve as a home for artistic expression and farmer’s markets.  It will also help to draw visitiors at Cole Park for events to the downtown.
Many of the plans being employed will be relying on impetus from business owners to get in on the action.
“We’re really looking this at a partnership with businesses to activate that space”
Owners are invited to take charge of back door spaces in conjunction with alley activation plans and storefront space created by a narrowed Main Street.  Giving owners a chance to flex their creative muscle, ideas have spanned Bags game set-ups and even oversized checkerboards. All of which hopefully takes Alamosa further down the path of accomplishing their goal of becoming a destination.
To view the downtown design plan be sure to visit https://cityofalamosa.org/wp-content/uploads/2019/11/Alamosa_Downtown-Design-Plan_FINAL_small.pdf

Business owners – to apply for a Façade Grant visit https://cityofalamosa.org/wp-content/uploads/2020/01/Facade-Grant-Program-Application.pdf
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These Are The Sickest Special Edition Muscle Cars Money Can Buy – HotCars

If a regular muscle car just isn’t special enough, there’s always the option of getting a special edition model.
The muscle car has been around longer than a lot of people realize, with the Oldsmobile Rocket 88 from 1949 widely accepted as the first of the breed. Since those humble beginnings, muscle cars have changed dramatically, every US carmaker jumping on the bandwagon, special editions the easiest way to stand out from the crowd.
Want the best muscle car with added bells and whistles? Grab one of the often higher-specced special editions crammed with extras, designed to be the baddest and sickest ride. On most occasions, motorsport links produce the best factory-made special editions, be it a homologation project car, commemorative anniversary model, or just an end-of-line custom paint job and power upgrade.
Chevrolet's sixth-generation Vette paid homage to the legendary GM 427 engine in 2008 with a special edition paint job and a limited production run of, yes, you guessed it, 427 cars.
Sadly, Chevrolet missed out on the opportunity to give the Z06 a power upgrade. The stock Corvette's 7-liter LS7 V8 remains at 505 hp, with a claimed top speed of 198 mph. Think of the 427 limited editions as dressed up Z06s. However, this Vette is all about celebrating GM's best muscle car engine, and with literally dozens of 427 logos inside and out, there is little chance gearheads or passers-by could forget.
Voodoo, Hellcat, Demon, can anyone spot a connection here? Dodge execs either have a fetish for the dark side or someone just thinks the baddest and most powerful cars sound better with names reflecting the kind of practices your local church frowns upon. Launched in 2017, Dodge gave the soon-to-be discontinued Viper a makeover in keeping with the Voodoo branding.
Beneath the murdered-out exterior, the same ACR-based set-up remained unchanged, the Voodoo merely a cosmetic job bestowing the Viper with a menacing look, and it worked. Under the hood, Dodge's 8.4-liter pushrod V10 delivers 645 hp and enough torque to reanimate the dead for a select few lucky gearheads.
RELATED: 10 Reasons Why The Dodge Viper Was A Success
If the Voodoo is a bit tame, then you need another of Dodge's mystical creations, the frighteningly fast and powerful SRT Demon. On the face of it, this is just a Challenger sporting a few extra bulges to give it a meaner look. And for good reason too, Demon isn't a strong enough name for this 211 mph asphalt-scorching monster.
Decked out with what Dodge refers to as the "Demon Crate" add-on, essentially a reduction in parts while adding a modified engine controller designed to boost its supercharged 6.2-liter V8 to a hefty 808 hp, even more, if you brim the tank with 100-octane racing fuel. Dodge managed to sell all 3,300 examples even before production had commenced.
1966 was a cracking year for the Ford Fairlane, wearing a new front end encompassing two stacked headlights made it stand out from the hum-drum of other car brands, and a huge leap over its predecessor, too. More importantly for muscle car fans, Ford produced a hotter special edition under the mysterious "Code-R" name tag.
The "R" referenced Racing or "Red-Alert" as we prefer to call it. The 500-R was equipped with Ford's 427 V8 and top-loader powertrain, which, if you believe the official numbers, produce 425 hp. Originally built to meet racing regulations, this special or limited edition muscle car is a rare sight, with just 57 examples completed.
Possibly the shortest production run of any car ever produced, the Ford Torino Talladega existed for just a few short weeks in 1969. Its sole purpose was to meet homologation regulations for the NASCAR series, and as soon as the job was done, Ford pulled the plug. 754 Talladegas were completed.
Despite the Torino nametag, the Talladega is based on the Fairlane Cobra fastback model equipped with Boss 429 engines separately homologated in Ford's Mustang. In the Talladega, Ford used modified rocker covers to lower the engine's installation height, saving an inch overall.
RELATED: We'd Love To Own These Modified Ford Torinos
Special Editions are usually the works of carmakers themselves, which makes the Baldwin-Motion GT rather unique. A by-product of Baldwin Chevrolet and Motion Performances collaboration, the Corvette GT Phase III was the baddest muscle car you could buy in 1969.
Still recognizable as Chevrolet's third-generation Vette, although subtle exterior changes, including different headlights, gave it a distinct appearance. It's under the hood where the big changes occurred, Motion Performance fettled the 427 motors, complete with Edelbrock intake and quad Holley carburetor set-up, to deliver a conservative 530 hp. Built to order, with no two Corvette GTs the same, only 10 Corvette GT's were produced.
In Britain, the muscle car is an altogether more refined beast, Aston Martin's Virage V8 Le Man's proved going fast by using a big engine didn't mean sacrificing the swathes of leather and wood trim. In Le Mans specification, the big British bruiser packed a 600 hp twin-supercharged 5.3-liter V8, promising a top speed over 200 mph.
In reality, Aston Martin was under ever-increasing pressure to meet emissions regulations and produced just 40 of these special edition Le Mans monsters. In the wings, a new breed of smaller, more modern Astons awaited launch.
All American Racers or AAR is all you need to know about the '70s limited edition Cuda, a faster, more powerful version of an already great muscle car. Plymouth produced a little over 2,700 in a mere two months during 1970.
Just one engine option was offered, Plymouth's own 340 cu in 6-barrel V8 producing 290 hp, driving the rear wheels via a 4-speed manual. In the right hands, a sub-six-second sprint to 60 mph was easily achievable. Externally identifiable by a deeper front air-dam, hood-mounted air scoop, and, of course, the AAR Cuda stripes.
RELATED: Dodge Challenger Vs Plymouth Barracuda: Which Was Chrysler's Best Classic Muscle Car?
In the Southern Hemisphere, where the Aussie Ute is the king of the road, Ford Australia gave gearheads their take on the muscle car with the special edition Falcon XY GT-HO
One of the rarest muscle cars on the road, the Falcon XY in Phase III guise is an understated performance sedan that rocked an all-American Cleveland 351 V8 delivering a pessimistic 300 hp. Why pessimistic? Like all muscle cars of the time, lower power figures mean lower insurance premiums. With no governing body checking on manufacturers' claims, carmakers got away with some surprising performance figures from horsepower numbers that didn't add up, the Phase III reaching sixty in 6.4-seconds.
Another homologation special guaranteed to get you noticed; the '69 Dodge Charger Daytona, one of the famous aero-cars sporting oversized rear wings and custom fabricated nose cones dubbed the "winged warriors".
Dodge produced 503 Daytonas, most equipped with Magnum 440 engines kicking out 375 hp, famously setting a new NASCAR record of 200 mph and claiming six victories over two seasons. Without question, the front nose cone played its part in racing success, but that rear wing, while increasing downforce, could have been much shorter, the extreme height keeping the rear trunk functional.
It seems a lot of people are willing to pay through the nose for a classic muscle car these days.
Raised in a car-obsessed environment from an early age ensured a keen interest in anything car-related. first and foremost an F1 fan, but also an avid follower of other motorsports. Professional background working closely with a well established UK based Supercar manufacturer in recent years.

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Best Magnesium Supplements to Take: Top 17 Product… – Islands' Sounder

Are you searching for magnesium supplements to boost up your immune health? I have tried out several magnesium products, and I know how taxing it can be to choose the correct form of magnesium. So why bother going through the numerous supplemental choices and make yourself more confused?
Here, in this article, we enumerated the best magnesium supplements that will keep your health in top shape.

Top 17 Magnesium Supplements of 2021

Here are some of the best quality magnesium supplements I have listed. These supplements will take care of your body’s magnesium needs.

Magnesium Breakthrough

If you are hunting for a magnesium supplement, then the Magnesium Breakthrough product will do wonders for you. Most of these supplements do not absorb correctly, but this particular product has a blend of various magnesium types that allow fast absorption.
These types include magnesium citrate, magnesium chelate, magnesium orotate, and magnesium bis-glycinate. This magnesium mineral is an essential component that your body requires. The lack of magnesium will make you suffer from sleep issues, anxiety, depression, and damage to your heart health.
Overall, this Magnesium Breakthrough product can offer support from a cellular level to help prevent such disruptions from occurring.

Magnesium L-Threonate

The best way to ensure magnesium sufficiency is by incorporating Magnesium L-Threonate in your diet. Their supplements contain the most sought-after magnesium L-threonate component, which absorbs super quickly.
Alongside its fast absorption, this magnesium form can efficiently increase brain magnesium levels to enhance your cognitive function.
This essential mineral takes care of blood pressure, nerve function, and muscle health. So you can imagine what magnesium deficiency can do to your body. However, incorporating this magnesium form can help improve your cognitive abilities and keep you healthy.
Since about 80% of your metabolic functions depend on magnesium, this magnesium L-threonate product will be an excellent choice for you.

Barton Nutrition EasyRelief Magnesium

Sometimes instead of a cocktail of magnesium forms, just a key ingredient may work more potently. The Barton Nutrition EasyRelief Magnesium contains a 100% magnesium chloride hexahydrate component.
This supplement not only helps with insulin sensitivity issues but also assists in keeping your blood glucose control.
An advantage of this magnesium product is that you do not have to take it orally. I know some people find oral supplements of such kind to be uncomfortable. Luckily, this product comes with a magnesium spray formula that you spray on your body.
All in all, you can keep your magnesium levels in check by getting this product.

Natural Stacks MagTech

A company uses distinctive magnesium forms to ensure their supplement contains the necessary magnesium components for your betterment; the Natural Stacks MagTech. The three forms are taurate, L-threonate, and glycinate. You can improve your brain health, muscle and nerve function, and overall muscle health.
What makes Natural Stacks MagTech stand out from other supplement companies? They provide third-party lab testing of their magnesium products.
Not many magnesium tablets out there undergo the testing procedures. Therefore, all of their label claims are authentic, and your body’s magnesium needs will not be insufficient.
So, you can take the Natural Stacks magnesium supplements to sleep better and support your nervous system.

Organixx Magnesium 7

As you can guess, this Organixx Magnesium 7 contains seven different supplemental magnesium forms that work together to provide the ultimate boost your body needs.
The blend of these magnesium forms helps deal with muscle cramps, blood pressure control, sleeplessness, anxiety, depression, heart problems, leg cramps, etc.
Dealing with a magnesium deficiency can be difficult, but the Organixx product comes at a reasonable price with superior benefits; you will not regret purchasing this supplement. Additionally, they provide the necessary third-party lab testing for each of their supplement bottles.
It also contains magnesium aspartate, a form that helps keep your cognitive abilities in a top-notch shape. Hence, the Organixx product delivers superior results.

1MD MagMD Plus

Sometimes, magnesium deficiency will occur even if you incorporate healthy food into your diet. That is because the absorption rate of magnesium varies a lot. Therefore, a healthy alternative is the 1MD MagMD Plus supplement because it contains forms that ensure elevated magnesium levels.
This magnesium supplement allows your body to function healthily, supports cardiovascular function, and improves your overall bone health. Long-time usage of MagMD Plus will result in all of these improvements, and you can check with your healthcare provider for the dosage level.
Moreover, aside from magnesium, this product has zinc and vitamin D3, which help to enhance the absorption rate, among other beneficial functions.
The MagMD product is extremely inexpensive compared to some other supplements, so that it will be an excellent magnesium tablet of choice for you.

Activation EASE

Are you in the search for a magnesium supplement that does not come in tablet form? Then check out the Activation EASE supplement that comes in a spray formula.
This natural magnesium solution can enter your bloodstream quickly. With each spray of Activation EASE, you get about 22 mg of magnesium. Hence, the higher absorption rate of magnesium also helps with the absorption of calcium.
Ultimately, it leads to downstream reactions that keep your body’s metabolic functions up to speed. Compared to some of the transdermal products out there, this magnesium supplement does not cause irritation or burning sensation when you spray it.
Therefore, the lack of elemental magnesium will not be an issue anymore if you introduce this magnesium supplementation in your diet.

Live Conscious MagWell

Choosing the correct magnesium supplement is problematic because it is a commitment. A small magnesium dosage may not provide you results.
Hence, you will have to repurchase the magnesium supplement of your choice quite a few times. So, an affordable product like the Live Conscious MagWell will come in handy.
This product helps support the musculoskeletal and cardiovascular systems of your body. Elemental magnesium helps to improve your body’s overall health. In particular, the MagWell product contains vitamin D3 alongside both zinc and magnesium.
Therefore, daily intake of the MagWell product will provide efficient results. Do not sleep on this excellent magnesium product that is super affordable.

Essential Elements Magnesium Plus

One capsule of magnesium a day can keep muscle soreness away. It may sound cheesy, but magnesium supplements can benefit you in several ways. Hence, let me introduce the Essential Elements Magnesium Plus product. It contains a trio of zinc, vitamin D3, and of course, magnesium.
Furthermore, you can significantly improve your health conditions thanks to this magnesium product. The forms of magnesium this product includes are magnesium malate, magnesium glycinate, and magnesium citrate. Plus, this product contains 180 capsules per bottle which last a long time.
Overall, the Essential Elements supplement is an excellent choice if you want to include a magnesium supplement.

Nuzena Magnesium Pure

If you want a magnesium product with a higher dosage and potency, then the Nuzena Magnesium Pure will be perfect. This product will provide about 400 mg of magnesium, especially the magnesium glycinate form. It contains the glycine amino acid that helps with sleep issues.
Moreover, the great thing about Nuzena Magnesium Pure is its packaging. Our human body requires magnesium for better calcium function and absorption. And this Nuzena product can do precisely that to keep your body healthy hence, one capsule of this supplement will help your bodily function.
If you are looking at the price and magnesium-related benefits, this Nuzena product delivers results flawlessly.

Transparent Labs Magnesium Bisglycinate

One of the most affordable forms of magnesium is bis-glycinate. This element provides anxiety relief, improves bone and heart health, helps with sleep issues, etc.
So, how can you make sure bis-glycinate is in your diet? Since your body cannot naturally produce bis-glycinate, a supplement like Transparent Labs Magnesium Bisglycinate will do the job.
This dietary supplement has a higher dosage of magnesium than your average supplements in the market. Furthermore, their clinical study ensures that the magnesium content of this product is enough to help improve your mood and deal with stress.
Interestingly, Transparent Labs also mentions how their product prevents genotoxicity, which affects your genes. So, you can benefit from this gluten-free magnesium supplement.

Pure Essence Iconic-Fizz Magnesium Plus

Just like any other supplement, magnesium supplements also require some time to show results. So, you may end up purchasing the same supplement several times, and that can be rather expensive.
The Pure Essence Iconic Fizz-Magnesium Plus is an excellent choice because it provides all magnesium-related benefits at an affordable range.
Each of its dosages contains 300 mg of magnesium carbonate, and overall, you get about 71% daily value. Additionally, it also contains potassium, beetroot powders, boron, etc. The critical point of the Fizz Plus product is that you can directly drink it. So you can say goodbye to magnesium tablets or sprays.
This magnesium product will be excellent for overall cardiovascular support, blood pressure maintenance, and healthy sleep pattern.

Moon Juice Magnesi-Om

Are you looking for ways to support your immune health from a cellular point? The Moon juice Magnesi-Om supplement will be perfect for you. This product contains three different bioavailable magnesium forms that work together to restore your cellular balance.
Unlike the other conventional magnesium supplements, this one helps keep your sense of focus at a top-notch state. Each Magnesi-Om dosage provides a mixture of 204 mg of magnesium citrate, 28 mg of magnesium taurinate, and 77 mg of magnesium gluconate.
The incredible thing about the Moon Juice is its transparency. Their magnesium product comes with all the information to know what you incorporate for educational and informational purposes.

Elm & Rye Magnesium

The essential mineral magnesium plays a crucial role in keeping your body in good shape. For this reason, the Elm & Rye Magnesium product will be a good option. Their minimalistic packaging also acts as an attraction.
Compared to the conventional magnesium supplements, the Elm & Rye one is more on the expensive side. However, they provide a highly potent magnesium product that primarily has magnesium gluconate and no fillers/preservatives.
If you prefer natural ingredients in your supplement rather than preservatives, the Elm & Rye will be your go-to option.
Overall, it is an excellent magnesium product that is gluten-free, soy-free, and dairy-free.

Natural Vitality Calm

Are you tired of magnesium supplements that come in tablet form? Here is the Natural Vitality Calm supplement that provides an excellent powder version of the supplement.
It contains several flavor forms; however, this particular Vitality Calm product is unflavored. Therefore, this supplement will be a great addition to your drinks.
Add 1 or 2 gm of the Natural Vitality supplement in the water of your favorite drink for easy preparation. Supplement incorporation in your diet will never get easier than this system. Furthermore, it contains a good amount of magnesium citrate and carbonate.
Interestingly, this Vitality product also provides a laxative effect. Compared to any other fiber drink, this magnesium product will help with your stool problems.

Thorne Research Magnesium Bisglycinate

A crucial element like magnesium can help with stress, depression, sleep issues, and so much more.
So, take a look at this Thorne Research Magnesium Bisglycinate product. With per serving, this magnesium product will provide 200 mg of the element. Such an amount is necessary to maintain the magnesium level of your body.
Not only does it provide optimal muscle support, but it also helps manage your blood glucose, heart, and brain health. If you did not know, this magnesium product might also help with menstrual cramps.
It contains bis-glycinate, monk fruit concentrate, citrate, among other forms of magnesium. Compared to other supplements, this Thorne one is an excellent choice.

Ancient Nutrition Magnesium

Sometimes, you can have magnesium-rich food in your diet, but that will not be enough. Dietary supplements like the Ancient Nutrition Magnesium ensure your body has sufficient magnesium for energy production.
This ultimately allows your bone strength, sleep, heart condition, etc., to improve immensely.
It contains a bunch of extracts and elements alongside zinc and magnesium to offer a range of help. Ancient Nutrition recommends three tablets for adults, but I suggest getting professional medical advice before incorporating this magnesium product.
Thanks to the Ancient Nutrition product, this crucial mineral may be hard to incorporate into your diet, but your magnesium needs will stay balanced.

How We Ranked The Top Magnesium Supplements

Here is how we ranked this magnesium product review to make sure you find the correct magnesium product.

Types of Magnesium

All these supplements contain several magnesium types that provide a range of effectivity.

Magnesium Oxide

Most magnesium supplements contain this magnesium oxide element. It not only helps with insomnia but also provides a pleasing laxative effect. So, incorporating magnesium oxide into your diet can be helpful.

Magnesium Citrate

Incorporating magnesium citrate will be a great option if you want to strengthen your heart, muscle, and bone health.

Magnesium Sulfate

This form of magnesium is essential for both plant and animal foods. In the case of animal foods, it primarily provides a laxative effect.

Magnesium Chloride

The magnesium chloride form helps deal with depression, lowering blood pressure, and can even help with inflammation.

Magnesium Glycinate

This popular magnesium glycinate form helps with your sleep problems. Since magnesium glycinate can enter the blood-brain barrier, it improves your brain’s health.
Overall, magnesium aspartate, magnesium oxide, magnesium sulfate, bis-glycinate, malate, etc., help manage your body.

Magnesium Supplement Dosage

Low magnesium levels can be problematic. Hence, the dosage of your magnesium product matters a lot. In this review, I have provided several magnesium dosage options that you can check.
Research shows that for adults, 350 mg of magnesium is more than enough. So the best magnesium dosage will be below 350 mg.

Top 17 Magnesium Supplements of 2021 Final Words

Since your body cannot create magnesium on its own, diet and supplements are the only ways to prevent magnesium shortage. But choosing the correct magnesium product is extremely difficult. Especially since dosage, forms of magnesium, and the price comes into play.
Hopefully, my list of the best magnesium supplements will help you choose more easily.
RELATED: Best Eye Vitamins for Vision Support (Top Supplements List)
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The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.
Disclaimer:
Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.
 
 
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Researchers Engineer a Mini CRISPR Genetic Editing System That Could Be Easier To Deliver Into Cells – SciTechDaily

By
CRISPR illustration. Credit: National Institutes of Health
A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study that was published on September 3, 2021, in the journal Molecular Cell.
“This is a critical step forward for CRISPR genome-engineering applications,” says senior study author Stanley Qi of Stanford University. “The work presents the smallest CRISPR to date, according to our knowledge, as a genome-editing technology. If people sometimes think of Cas9 as molecular scissors, here we created a Swiss knife containing multiple functions. It is not a big one, but a miniature one that is highly portable for easy use.”
The development of CRISPR-Cas systems for human cells has revolutionized genome engineering. These systems offer opportunities for the development of gene therapies for a variety of genetic diseases. But their large sizes often restrict delivery into cells and thus impede clinical applications. For example, adeno-associated virus (AAV), a vector widely applied for in vivo delivery, has limited packaging capacity of the payload (less than 4.7 kb), and many Cas fusion proteins are beyond this limit. As a result, there is a need to engineer highly efficient, compact Cas systems to facilitate the next generation of genome-engineering applications.
One potential solution is Cas12f, also known as Cas14. Ranging between 400 and 700 amino acids, the protein is less than half the size of currently used CRISPR systems such as Cas9 or Cas12a. But until now, it was not clear whether this compact protein could be used in mammalian cells. “Recent years have identified thousands of CRISPRs, which are known as bacteria’s immunity defense system,” Qi explains. “More than 99.9% of discovered CRISPRs, however, cannot work in human cells, limiting their use as genome-editing technologies.”
In the new study, Qi and his team applied <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="

RNA
Ribonucleic acid (RNA) is a polymeric molecule similar to DNA that is essential in various biological roles in coding, decoding, regulation and expression of genes. Both are nucleic acids, but unlike DNA, RNA is single-stranded. An RNA strand has a backbone made of alternating sugar (ribose) and phosphate groups. Attached to each sugar is one of four bases—adenine (A), uracil (U), cytosine (C), or guanine (G). Different types of RNA exist in the cell: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA).

“>RNA and protein engineering to the Cas12f system to generate an efficient miniature Cas system for mammalian genome engineering. Derived from archaea, the natural Cas12f protein and its single-guide RNA showed no detectable activity in mammalian cells. By optimizing the single-guide RNA design and performing multiple rounds of iterative protein engineering and screening, the researchers generated a class of Cas12f variants named CasMINI.
The engineered Cas12f protein variants combined with engineered single-guide RNAs exhibited efficient gene-regulation and gene-editing activity. The researchers demonstrated that CasMINI can drive high levels of gene activation comparable to those associated with Cas12a and allows for robust base editing and gene editing. Moreover, it is highly specific and does not produce detectable off-target effects.
“Here we turn a non-working CRISPR in mammalian cells, via rational RNA engineering and protein engineering, into a highly efficient working one,” Qi says. “There were previous efforts from others to improve the performance of working CRISPRs. But our work is the first to make a non-working one working. This highlights the power of bioengineering to achieve something evolution has not yet done.”
The size of the engineered CasMINI molecule is only 529 amino acids. This small size makes it suitable for a wide range of therapeutic applications. For example, the CasMINI fusion proteins are well suited for AAV packaging. In addition, CasMINI mRNA can be easily packaged into lipid nanoparticles or other RNA-delivery modalities, potentially enhancing its entry into cells. Its small size and non-human pathogen source might make it less likely to produce immune responses than large protein payloads would be.
More work is needed to further optimize the efficiency of CasMINI for base editing and gene editing and to test the performance of the system in vivo with different delivery modalities. The researchers plan to test the system for in vivo gene-therapy applications.
“The availability of a miniature CasMINI enables new applications, ranging from in vitro applications such as engineering better tumor-killing lymphocytes or reprogramming stem cells to in vivo gene therapy to treat genetic diseases in the eye, muscle, or liver,” Qi says. “It is on our wish list that it will become a therapy to treat genetic diseases, to cure cancer, and to reverse organ degeneration.”
For more on this mini CRISPR system, see “Mini” CRISPR Genetic Editing System Engineered.
Reference: “Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing” by Xiaoshu Xu, Augustine Chemparathy, Leiping Zeng, Hannah R. Kempton, Stephen Shang, Muneaki Nakamura and Lei S. Qi, 3 September 2021, Molecular Cell.
DOI: 10.1016/j.molcel.2021.08.008
This work was supported by the Pew Scholar Foundation, the Alfred P. Sloan Foundation, and the Li Ka Shing Foundation. L.S.Q. is a founder and shareholder of Epicrispr Biotechnologies and Refuge Biotechnologies. L.S.Q. is a member of the scientific advisory board of Epicrispr Biotechnologies and Refuge Biotechnologies. The authors have filed provisional patents via Stanford University related to the work.
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Delhi – Jaipur Highway To Be Made Electric Highway With Buses And Trucks Powered By Electricity Like Rail Engines – Swarajya

The Ministry of Road Transport and Highways is in talks with a foreign company to construct an electric highway from Delhi to Jaipur.
While reviewing the Delhi – Mumbai Expressway (DME) at Dausa in Rajasthan, Union Road Transport and Highways Minister Nitin Gadkari said that, like electric railway engines, buses and trucks will also be powered by electricity on an electric highway.
“It is my dream to build an electric highway from Delhi to Jaipur. It is still a proposed project. We are in discussion with a foreign company,” he said, reports The Indian Express.
On a two day visit, Nitin Gadkari reviewed work progress on the Delhi-Mumbai Expressway at Sohna in Haryana, Dausa and Bundi in Rajasthan, Ratlam in Madhya Pradesh.
Being developed at Rs 98,000 crores, the 1,380 km long Delhi Mumbai expressway will be the longest in India.
The greenfield expressway is expected to halve the commute time between Delhi and Mumbai from nearly 24 hours to 12 hours and shorten the distance by 130 km.
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