NASA Spaceline Current Awareness List # 971 15 October 2021 (Space Life Science Research Results) – Space Ref

Status Report From: Spaceline
Posted: Friday, October 15, 2021

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected].
 
Papers deriving from NASA support:
 
1
Manian V, Orozco-Sandoval J, Diaz-Martinez V.
An integrative network science and artificial intelligence drug repurposing approach for muscle atrophy in spaceflight microgravity.
Front Cell Dev Biol. 2021 Sep 16;9:732370.
PI: H. Janwa
Note: ISS results. This article and an article below (Locatelli et al.) in the “Other” section are part of Research Topic “Space Mechanobiology and Medicine” (https://www.frontiersin.org/research-topics/17450/space-mechanobiology-and-medicine#articles). The Research Topic also includes articles from previous Current Awareness List #963 https://doi.org/10.3389/fcell.2021.672098, https://doi.org/10.3389/fcell.2021.689662, and https://doi.org/10.3389/fcell.2021.707470. Additional articles will be forthcoming and may be found in the link to the Research Topic. GeneLab is available at https://genelab.nasa.gov. This article may be obtained online without charge.
Journal Impact Factor: 2.7
Funding: “This research was funded by NASA EPSCoR (Grant Number 80NSSC20M0132).”
 
2
Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI.
Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation.
Redox Biol. 2021 Nov;47:102132. Available online 20 September 2021.
PI: C. Chung
Note: This article may be obtained online without charge.
Journal Impact Factor: 11.799
Funding: “This work was partially supported by grants from the National Institutes of Health (NIH) to Drs. Abe (AI-156921), Maggirwar (HL-123346), Schifitto (HL-123346), Cooke (HL-149303), Le (HL-134740 and HL-149303), National Aeronautics and Space Administration (NASA) to Dr. Caroline Chung (80NSSC18K1639 P00007), and from Cancer Prevention and Research Institute of Texas (CPRIT) to Drs. Abe and Schadler (RP190256). This research performed in the Flow Cytometry and Cellular Imaging Facility (NC) is supported in part by the National Institutes of Health through MD Anderson’s Support Grant CA016672.”
 
The article below previously appeared in the “Other” section of CA List #969 due to NASA funding not appearing in the funding acknowledgment.
3
Mao T, Dinges D, Deng Y, Zhao K, Yang Z, Lei H, Fang Z, Yang FN, Galli O, Goel N, Basner M, Rao H.
Impaired vigilant attention partly accounts for inhibition control deficits after total sleep deprivation and partial sleep restriction.
Nat Sci Sleep. 2021 Sep 16;13:1545-60.
PI: N. Goel
Note: This article may be obtained online without charge.
Journal Impact Factor: 5.346
Funding: “This research was supported in part by the grants from National Institutes of Health (R01-HL102119, R01- MH107571, R21-AG051981, and CTRC UL1RR024134), Shanghai International Studies University Research Projects (Grant number 20171140020), Shanghai Post-doctoral Excellence Program (Grant number 2020367), China Postdoctoral Science Foundation (Grant number 2021M692150), National Natural Science Foundation of China (Grant Number 71942003), and South China Normal University.” PI reports funding from NASA grant 80NSSC20K0243.
 
4
Yamazaki EM, Casale CE, Brieva TE, Antler CA, Goel N.
Concordance of multiple methods to define resiliency and vulnerability to sleep loss depends on Psychomotor Vigilance Test metric.
Sleep. 2021 Oct 8;zsab249. Online ahead of print.
PI: N. Goel
Journal Impact Factor: 5.849
Funding: “This work was primarily supported by the Department of the Navy, Office of Naval Research (Award No. N00014-11-1-0361) to N.G. Other support provided by National Aeronautics and Space Administration (NASA) grant NNX14AN49G and grant 80NSSC20K0243 (to N.G.), National Institutes of Health grant NIH R01DK117488 (to N.G.) and Clinical and Translational Research Center grant UL1TR000003.”
 
5
Mortreux M, Rosa-Caldwell ME, Stiehl ID, Sung DM, Thomas NT, Fry CS, Rutkove SB.
Hindlimb suspension in Wistar rats: Sex-based differences in muscle response.
Physiol Rep. 2021 Oct;9(19):e15042.
PI: S.B. Rutkove
Note: Hindlimb unloading study. This article may be obtained online without charge.
Journal Impact Factor: 2.053
Funding: “This work was supported by a grant from the National Aeronautics and Space Administration (NASA: 80NSSC19K1598, PI: SBR) and the Stamps Scholarship (IDS).”
 
6
Spatz JM, Ko FC, Ayturk UM, Warman ML, Bouxsein ML.
RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice.
PLoS One. 2021 Oct 12;16(10):e0250715.
PI: M.L. Bouxsein
Note: Hindlimb unloading study. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “This work supported by funding from National Aeronautics and Space Administration (NNX10AE39G) and from the National Institutes of Health (R21AR057522 and R01AR053237).”
 
_______________________________________________________
 
 
Other papers of interest:
 
1
Choukér A, Ngo-Anh TJ, Biesbroek R, Heldmaier G, Heppener M, Bereiter-Hahn J.
European Space Agency’s hibernation (torpor) strategy for deep space missions: Linking biology to engineering.
Neurosci Biobehav Rev. 2021 Dec;131:618-26. Review. Available online 1 October 2021.
Note: From the abstract: “Long-duration space missions to Mars will impose extreme stresses of physical and psychological nature on the crew, as well as significant logistical and technical challenges for life support and transportation. Main challenges include optimising overall mass and maintaining crew physical and mental health. These key scopes have been taken up as the baseline for a study by the European Space Agency (ESA) using its Concurrent Design Facility (CDF). It focussed on the biology of hibernation in reducing metabolism and hence stress, and its links to the infrastructure and life support.”
 
2
Zu Eulenburg P, Buchheim JI, Ashton NJ, Vassilieva G, Blennow K, Zetterberg H, Choukér A.
Changes in blood biomarkers of brain injury and degeneration following long-duration spaceflight.
JAMA Neurol. 2021 Oct 11. Online ahead of print.
Note: From the abstract: “Long-duration spaceflight has a widespread effect on human physiology. The past decade first revealed eyeball alterations, and then neuroimaging studies hinted at potentially detrimental effects on the brain.Expansion of cerebrospinal fluid spaces occurs at the cost of the gray and white matter compartment. A neurobiological integrity assessment of the brain’s tissues after prolonged exposure to microgravity has never been conducted, to our knowledge. Therefore, we investigated the longitudinal course of blood-based biomarkers representing the brain parenchyma in long-duration spaceflight.”
 
3
Hatakeyama J, Nomura M, Wakimoto Y, Inoue S, Li C, Takamura D, Akisue T, Moriyama H.
Effects of cyclic tensile strain and microgravity on the distribution of actin fiber and Fat1 cadherin in murine articular chondrocytes.
J Biomech. 2021 Dec 2;129:110774. Available online 29 September 2021.
Note: A 3D clinostat was used in this study.
 
4
Locatelli L, Maier JAM.
Cytoskeletal remodeling mimics endothelial response to microgravity.
Front Cell Dev Biol. 2021 Sep 9;9:733573.
Note: A rotating wall vessel was used in this study. This article and an article above (Manian et al.) in the “NASA” section are part of Research Topic “Space Mechanobiology and Medicine” (https://www.frontiersin.org/research-topics/17450/space-mechanobiology-and-medicine#articles). This article may be obtained online without charge.
 
5
Morbidelli L, Genah S, Cialdai F.
Effect of microgravity on endothelial cell function, angiogenesis, and vessel remodeling during wound healing.
Front Bioeng Biotechnol. 2021 Sep 22;9:720091. Review.
Note: This article is part of Research Topic “Wound Management and Healing in Space” (https://www.frontiersin.org/research-topics/14877/wound-management-and-healing-in-space#articles). The Research Topic also includes an article from previous Current Awareness List #958 https://doi.org/10.3389/fbioe.2021.679650. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
 
6
Nandi A, Virmani G, Barve A, Marathe S.
DBscorer: An open source software for automated accurate analysis of rodent behavior in forced swim test and tail suspension test.
eNeuro. 2021 Oct 8;ENEURO.0305-21.2021. Online ahead of print.
Note: Hindlimb unloading study. This article may be obtained online without charge.
 
7
Takemoto R, Sejima T, Han LK, Michihara S, Takahashi R.
Disuse muscle atrophy-improving effect of ninjin’yoeito in a mouse model.
Neuropeptides. 2021 Dec;90:102199. Available online 23 September 2021.
Note: Hindlimb unloading study.
 
8
Anani T, Castillo AB.
Mechanically-regulated bone repair.
Bone. 2021 Oct 6;116223. Review. Online ahead of print.
 
9
Kang X, Jiang L, Lan F, Tang YY, Zhang P, Zou W, Chen YJ, Tang XQ.
Hydrogen sulfide antagonizes sleep deprivation-induced depression- and anxiety-like behaviors by inhibiting neuroinflammation in a hippocampal Sirt1-dependent manner.
Brain Res Bull. 2021 Oct 5;S0361-9230(21)00294-X. Online ahead of print.
 
10
Smulligan KL, Wilson JC, Seehusen CN, Wingerson MJ, Magliato SN, Howell DR.
Post-concussion dizziness, sleep quality, and postural instability: A cross-sectional investigation.
J Athl Train. 2021 Oct 8. Online ahead of print.
Note: This article may be obtained online without charge.
 
11
Lone SR, Potdar S, Venkataraman A, Sharma N, Kulkarni R, Rao S, Mishra S, Sheeba V, Sharma VK.
Mechanosensory stimulation via nanchung expressing neurons can induce daytime sleep in Drosophila.
J Neurosci. 2021 Oct 11;JN-RM-0400-21. Online ahead of print.
 
12
Qin F, Liu N, Nie J, Shen T, Xu Y, Pan S, Pei H, Zhou G.
Circadian effects of ionizing radiation on reproductive function and clock genes expression in male mouse.
Environ Health Prev Med. 2021 Oct 11;26(1):103.
Note: This article may be obtained online without charge.
 
13
Soyuyuce OG, Dikmen PY, Korkut N.
The effect of migraine and motion sickness on symptoms evoked by the caloric vestibular test.
J Vestib Res. 2021 Sep 29. Online ahead of print.
 

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